Inventors:
Erik R. Eastlund - Fenton MO, US
Greg D. Davis - Webster Groves MO, US
Derek K. Douglas - St. Louis MO, US
David K. Stone - Omaha NE, US
Assignee:
SIGMA ALDRICH COMPANY - St. Louis MO
International Classification:
C12N 15/87, C07H 21/04
Abstract:
The present invention provides methods modified oligonucleotides and methods of using the modified oligonucleotides for silencing nucleic acids, wherein the nonspecific effects of nucleic acid silencing are reduced.