Inventors:
David Pellman - Boston MA, US
Assignee:
Dana-Farber Cancer Institute, Inc. - Boston MA
International Classification:
C07H 21/02, C07H 21/04, A61K 31/70, C12Q 1/68
US Classification:
514 44A, 536 231, 536 241, 536 245, 435375, 435377
Abstract:
The invention provides methods of treating a meiotic kinase-associated disease, preferably the meiotic kinase HSET, by administering an inhibitor of the meiotic kinase. Preferably, the disease is associated with the presence of supernumerary centrosomes, such as cancer. Methods of inhibiting the growth of a tumor cell by contacting the cell with an inhibitor of a meiotic kinase, preferably HSET, are also provided. Screening methods for identifying inhibitors of the meiotic kinase HSET are also provided. Methods of selecting subjects for treatment with an inhibitor of a meiotic kinase, such as HSET, are also provided.