David Stephen Terman
Physician in Pebble Beach, CA
License number
Colorado 17920
Issued Date
Jan 9, 1973
Renew Date
Jun 1, 2007
Expiration Date
May 31, 2009
Type
Physician
Address
Address
PO Box 987, Pebble Beach, CA 93953
Professional information
Dr. David S Terman - MD (Doctor of Medicine)
Hospitals:
3183 Palmero Way, Pebble Beach 93953
3183 Palmero Way, Pebble Beach 93953
3183 Palmero Way, Pebble Beach 93953
Education:
Medical Schools
George Washington University / School of Medicine And Health Sciences
George Washington University / School of Medicine And Health Sciences
Tumor Killing Effects Of Enterotoxins, Superantigens, And Related Compounds
US Patent:
6338845, Jan 15, 2002
Filed:
May 18, 1999
Appl. No.:
09/314235
Inventors:
David S. Terman - Pebble Beach CA 93953
International Classification:
A01N 6300
US Classification:
424 931, 424 932, 424 9321, 424 937, 424 9371, 435372, 4353721, 4353722, 4353723
Abstract:
Superantigens, including staphylococcal enterotoxins, are useful agents for killing tumor cells, enhancing antitumor immunity and treating cancer in a tumor-bearing host. Other useful superantigens include Streptococcal pyrogenic exotoxin, toxic shock syndrome toxins, mycoplasma antigens, mycobacteria antigens, minor lymphocyte stimulating antigens, heat shock proteins, stress peptides and derivatives thereof. The immune system of a subject with cancer is contacted with tumor cells that have been transfected with a nucleic acid encoding a superantigen or biologically active polypeptide of a superantigen. Alternatively, transfected accessory cells, inmunocytes or fibroblasts are used. Expression of the superantigen in the host induces T cell proliferation leading to increased antitumor immunity and tumor cell killing. The superantigen encoding nucleic acid may be administered to the tumor in vivo to transfect tumor cells, wherein superantigen expression induces a tumoricidal immune response. Furthermore, transfected cells incubated ex vivo with an immunocyte population, particularly T lymphocytes, tumoricidally activate the population; such activated cells are then administered to the tumor-bearing host.
Superantigen Based Methods And Compositions For Treatment Of Diseases
US Patent:
6340461, Jan 22, 2002
Filed:
Dec 17, 1997
Appl. No.:
08/992877
Inventors:
David Stephen Terman - Pebble Beach CA 93953
International Classification:
A61K 39385
US Classification:
4241931, 4241921, 4241941, 4242771, 4242781, 4242801, 4242821, 435 681, 435 691, 435 693, 435 697
Abstract:
The present invention relates to therapeutic methods and compositions employing superantigens. Methods and compositions employing superantigens and immunotherapeutic proteins in combination with one another have been found to provide more effective treatment than either component used alone. Superantigens, in conjunction with one or more additional immunotherapeutic antigens, may be used to either induce a therapeutic immune response directed against a target or to inhibit a disease causing immune response. Specific combinations of superantigens and immunotherapeutic antigens are used to treat specific diseases. The induction (or augmentation) of a desired immune against a target may be used, for example, to kill cancer cells or kill the cells or an infectious agent. The inhibition of an immune response, e. g. , through the induction of T cell anergy, may be used to reduce the symptoms of an autoimmune disease.
Sickled Erythrocytes, Nucleated Precursors & Erythroleukemia Cells For Targeted Delivery Of Oncolytic Viruses, Anti-Tumor Proteins, Plasmids, Toxins, Hemolysins & Chemotherapy
US Patent:
2010020, Aug 12, 2010
Filed:
May 29, 2007
Appl. No.:
12/302655
Inventors:
David S. Terman - Pebble Beach CA, US
Mark W. Dewhirst - Durham NC, US
Mark W. Dewhirst - Durham NC, US
International Classification:
A61K 48/00, C12N 5/071, C12N 5/09, C12N 5/095, A61P 35/04
US Classification:
424 9321, 435325, 530350
Abstract:
The present invention provides erythrocytes or nucleated erythrocyte precursors from animals or patients with SS or SA hemoglobin or erythroleukemia cells stably transfected with BCAM/Lu which are capable of selectively localizing in tumor vasculature promoting ischemia and occlusion and carrying oncolytic viruses, antitumor proteins, plasmids, toxins and chemotherapy into the tumor milieu. Nucleated erythroid precursors containing SS or SA hemoglobin and transfected with nucleic acids encoding a hypoxia-responsive element and containing nucleic acids encoding expression of oncolytic viruses, superantigens, toxins, viruses, antitumor proteins and chemotherapy are also useful in inducing a potent and specific tumoricidal response. An especially favored carrier is an SS nucleated erythroid precursor transfected with a replication competent oncolytic adenovirus or self-replicating alphavirus expressing a fusogenic membrane glycoprotein or a tumoricidal polypeptide.
Knowledge Acquisition Nexus For Facilitating Concept Capture And Promoting Time On Task
US Patent:
8488916, Jul 16, 2013
Filed:
Jul 20, 2012
Appl. No.:
13/554398
Inventors:
David S Terman - Pebble Beach CA, US
International Classification:
G06K 9/22, G06K 9/00, G06F 17/27, G06F 17/00
US Classification:
382315, 382187, 704 9, 715254
Abstract:
Described herein is an interactive digital software program and hardware that enables rapid acquisition of textual or audio subject matter, its conversion to editable text and immediate compression into a user understandable summary. The software program maximizes “time on task” while minimizing the time-consuming steps of “concept capture” and “compression”. The instant invention provides an accurate condensate of textual subject matter in a fraction of the time it would take to prepare such a document by manual note taking. In a single step, mobile devices such as cameras, camera phones, tablets, iPODs™, scanners and the like rapidly capture textual images convert them to OCR and to a user understandable summary in a fraction of the time it takes to process such a document by manual note taking. With more study time available for repetitious practice of the lesson, the user improves preparedness and performance on tests and presentations.
Compositions And Methods For Treatment Of Neoplastic Disease
US Patent:
2011005, Mar 10, 2011
Filed:
Aug 20, 2010
Appl. No.:
12/860699
Inventors:
David S. Terman - Pebble Beach CA, US
International Classification:
A61K 38/16, A61P 35/00
US Classification:
514 193
Abstract:
The present invention comprises compositions and methods for treating a tumor or neoplastic disease in a host, The methods employ conjugates comprising superantigen polypeptides or nucleic acids with other structures that preferentially bind to tumor cells and are capable of inducing apoptosis. Also provided are superantigen-glycolipid conjugates and vesicles that are loaded onto antigen presenting cells to activate both T cells and NKT cells. Cell-based vaccines comprise tumor cells engineered to express a superantigen along with glycolipids products which, when expressed, render the cells capable of eliciting an effective anti-tumor immune response in a mammal into which these cells are introduced. Included among these compositions are tumor cells, hybrid cells of tumor cells and accessory cells, preferably dendritic cells. Also provided are T cells and NKT cells activated by the above compositions that can be administered for adoptive immunotherapy.
Method Of Cancer Treatment
US Patent:
6251385, Jun 26, 2001
Filed:
Jul 22, 1997
Appl. No.:
8/898903
Inventors:
David S. Terman - Pebble Beach CA
International Classification:
A01N 6300, A01N 6500, A61K 3902, A61K 39085
US Classification:
424 937
Abstract:
Treatment of solid tumors, including their metastases, without radiation, surgery or standard chemotherapeutic agents is described. Ex vivo stimulation of cells, selection of specific V. beta. subsets of stimulated cells and reinfusion of the V. beta. subsets of stimulated cells is employed for cancer therapy.
Method Of Cancer Treatment
US Patent:
2002005, May 2, 2002
Filed:
Dec 19, 2000
Appl. No.:
09/741503
Inventors:
David Terman - Pebble Beach CA, US
International Classification:
A61K045/00, A61K039/00, C12N005/08
US Classification:
424/093700, 435/372000
Abstract:
Treatment of solid tumors, including their metastases, without radiation, surgery or standard chemotherapeutic agents is described. Ex vivo stimulation of cells, selection of specific V subsets of stimulated cells and reinfusion of the V subsets of stimulated cells is employed for cancer therapy.
Compositions And Methods For Treatment Of Neoplastic Disease
US Patent:
8524218, Sep 3, 2013
Filed:
Nov 24, 2008
Appl. No.:
12/276941
Inventors:
David S Terman - Pebble Beach CA, US
International Classification:
A01N 63/02
US Classification:
424 931, 424 9321, 435372
Abstract:
The present invention comprises the use of sickle cells or sickle cell precursors loaded with a therapeutic agent that localize in tumors and induce a tumoricidal response.
Compositions And Methods For Treatment Of Cancer
US Patent:
2012014, Jun 14, 2012
Filed:
Oct 20, 2011
Appl. No.:
13/317590
Inventors:
David S. Terman - Pebble Beach CA, US
International Classification:
A61K 38/16, A61P 35/00, A61P 37/04, C07K 19/00
US Classification:
4242821, 5303873, 530350
Abstract:
The present invention contemplates therapeutic constructs comprising superantigen homologues devoid of neutralizing antibodies in human sera conjugated recombinantly to costimulatory and tumor targeting molecules for treatment of cancer