Inventors:
Benjamin Bonavida - Los Angeles CA, US
Lee Goodglick - Los Angeles CA, US
Hermes Gaban - Los Angeles CA, US
Stephan Horvath - Los Angeles CA, US
David Seligson - Los Angeles CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 49/00, C07H 21/04, A61P 35/00, A61K 33/00, A61K 31/7105, G01N 33/574, C12Q 1/68, C12Q 1/02
US Classification:
424 91, 536 2433, 424718, 514 44, 435 723, 435 6, 435 29
Abstract:
The present invention provides for the first time YY1, a transcription factor gene over-expressed and/or functionally overactive in human cancer. The present invention provides methods of diagnosing and providing a prognosis for cancer such as prostate cancer, as well as methods of drug discovery. YY1 is also a therapeutic target for treatment of cancer resistant to conventional and experimental cancer therapeutics. Inhibition of YY1 expression and/or activity sensitizes resistant tumor cells to cytotoxic treatments, including chemotherapy, radiation therapy, hormonal therapy, and immunotherapy.