DAVID SCOTT BROWN
Pilots at Santa Luz Path, League City, TX
License number
Texas A2536314
Issued Date
Dec 2016
Expiration Date
Jun 2017
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
2397 Santa Luz Path, League City, TX 77573
Professional information
Single-Stranded End-Capped Oligonucleotide Mediated Targeted Gene Repair And Modification And Uses Thereof
US Patent:
2004002, Feb 5, 2004
Filed:
Aug 14, 2001
Appl. No.:
09/767775
Inventors:
Brian Davis - Houston TX, US
David Brown - League City TX, US
David Brown - League City TX, US
International Classification:
A61K048/00
US Classification:
514/044000
Abstract:
The present invention relates to the field of transfer of small molecules of exogenous nucleic acid into living cells, and to improved methods for accomplishing same using the technique of single-stranded end-capped oligonucleotide gene repair. In some embodiments, the inventive method may be further described as providing incorporation of said materials into cells that can be made to exist in an adherent state in vitro. The invention also relates to the field of microinjecting said materials into living cells with improved cell viability for the injected cells. As well, the invention describes a method for improved genetic modification of endogenous sequences using co-delivery of accessory proteins and oligonucleotides to facilitate modification. The invention further relates to the field of gene therapy, using the technique of single-stranded end-capped oligonucleotide gene repair to correct genetic defects, as well as introducing specific mutations into genomic DNA for use in functional genomics. In some embodiments the invention may be used to introduce specific genetic mutations into selected genes of living cells for the purpose of generating transgenic mice, isogenic cell lines, primary cell types carrying a specific mutation, genetically modified plant cells, validation of gene function, and including, but not limited to, disease gene discovery.
Fault Tolerant Apparatus And Method For Determining A Revolution Rate Of A Gear
US Patent:
2003020, Nov 6, 2003
Filed:
May 2, 2002
Appl. No.:
10/136334
Inventors:
David Brown - League City TX, US
Matthew Meyer - Irvine CA, US
Ajay Mishra - Irvine CA, US
Jeffrey Norris - Lake Forest CA, US
David Rasmussen - Placentia CA, US
Matthew Meyer - Irvine CA, US
Ajay Mishra - Irvine CA, US
Jeffrey Norris - Lake Forest CA, US
David Rasmussen - Placentia CA, US
International Classification:
G06F019/00
US Classification:
702/079000
Abstract:
An apparatus comprises an edge detector, a memory and a pulse-input engine. The edge detector is configured to receive an input signal and a counter signal. The edge detector is further configured to send a set of time values based on the input signal and the counter signal. Each time value from the set of time values is uniquely associated with a detected edge transition from the input signal. The memory is coupled to the edge detector. The memory is configured to receive from the edge detector the set of time values. The memory is configured to store the set of time values. The pulse-input engine is coupled to the memory. The pulse-input engine is configured to measure a set of pulse-to-pulse delays based on the set of time values stored in the memory.