DAVID SANFORD SCHWARTZMAN
Medical Practice in Pittsburgh, PA

6663627, Dec 16, 2003

Apr 24, 2002

10/132392

David E. Francischelli - Anoka MN
Eduardo N. Warman - Maple Grove MN
Rahul Mehra - Stillwater MN
Mark T. Stewart - Lino Lakes MN
James R. Skarda - Lake Elmo MN
Harry Puryear - Shoreview MN
David Schwartzman - Pittsburgh PA

Medtronic, Inc. - Minneapolis MN

A61B 1818

606 41, 606 34, 607122

A system and method for creating lesions and assessing their completeness or transmurality. Assessment of transmurality of a lesion is accomplished by monitoring the depolarization signal amplitude in a local electrogram taken using electrodes located adjacent the tissue to be ablated. Following onset of application of ablation energy to heart tissue, the amplitude of a local electrogram measured with electrodes located adjacent tissue to be ablated first gradually drops and then stabilizes, indicating that the tissue being monitored has ceased making any contribution to the sensed electrogram. The amplitude drop and/or the following amplitude plateau may be used alone or together as indicators of transmurality. Detection of a rapid drop in amplitude may be employed as an indicator that the ablation process is proceeding too quickly and may be employed to trigger a reduction in the power of applied ablation energy. Detection of an insufficiently rapid drop in amplitude may be employed as an indicator that the ablation process is proceeding too slowly and may be employed to trigger an increase in the power of applied ablation energy.

2013019, Aug 1, 2013

Jan 28, 2013

13/751414

David SCHWARTZMAN - Pittsburgh PA, US
Lee E. Weiss - Pittsburgh PA, US
Phil Gordon Campbell - Cranberry Township PA, US
Gary K. Fedder - Turtle Creek PA, US

CARNEGIE MELLON UNIVERSITY - Pittsburgh PA
University of Pittsburgh-of the Commonwealth System of Higher Education - Pittsburgh PA

A61M 5/00

604500, 424 9372, 514773, 514772, 424 931, 4241301, 604 9301

Methods and apparatuses for delivery of biologically active material and/or sensors to a target organ or system. The apparatuses allow for specific, controlled delivery of the biologically active material and targeted placement of sensors. The apparatuses may be fabricated from cellular and/or acellular biological active components to promote integration of sensors into tissue and achieve appropriate release of biologically active molecules. The apparatuses may be fabricated from plasma-containing materials or other biopolymers such that the apparatus will resorbed into the tissue following insertion. The biologically active cellular or acellular component may be incorporated into that material may then serve as the source of the therapeutic biologically active component. The apparatus may take the form of a screw, though numerous shapes arc contemplated. The delivery methods and apparatuses of the present invention may be employed in a wide variety of physiological and medical situations, with cardiac implementations being particularly appropriate.

8480588, Jul 9, 2013

Jun 23, 2011

13/167400

Takeo Kanade - Pittsburgh PA, US
David Schwartzman - Pittsburgh PA, US
Hua Zhong - Pittsburgh PA, US

Carnegie Mellon University - Pittsburgh PA
University of Pittsburgh—Of the Commonwealth System of Higher Education - Pittsburgh PA

A61B 8/00, A61B 5/05, G06K 9/00

600443, 600425, 382128

A method and a system for producing images of a subject, such as the heart of a human being. The method may comprise acquiring ultrasound images of the subject with a catheter comprising a position sensor. The method may also comprise capturing a plurality of 4D surface registration points in the acquired ultrasound images corresponding to points on the subject. The method may also comprise registering, in space and time, a high-resolution 4D model of the subject with the plurality of 4D surface registration points. The method may also comprise displaying high resolution, real-time images of the subject during a medical procedure based on the registration of the high resolution 4D model to the 4D surface registration points. Embodiments of the present invention are especially useful in left atrium ablation procedures.

8007504, Aug 30, 2011

Mar 24, 2009

12/410323

Marco Zenati - Pittsburgh PA, US
David S. Schwartzman - Pittsburgh PA, US
Mark J. Gartner - Wexford PA, US
Daniel T. McKeel - Pittsburgh PA, US

University of Pittsburgh of The Commonwealth System of Higher Education - Pittsburgh PA

A61B 17/08, A61B 17/22

606151, 606115, 606127, 600129

A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the LAA through various non-invasive means. After capturing the LAA with the devices and methods provided, a clamping device is preferably disposed about the base of the appendage. In certain embodiments, the appendage remains viable subsequent to the functional occlusion of the lumen.

7981038, Jul 19, 2011

Oct 11, 2006

12/083044

Takeo Kanade - Pittsburgh PA, US
David Schwartzman - Pittsburgh PA, US

Carnegie Mellon University - Pittsburgh PA
University of Pittsburgh - of the Commonwealth System of Higher Education - Pittsburgh PA

A61B 8/00, A61B 5/05, G06K 9/00

600443, 600425, 382128

A method and a system for producing images of a subject, such as the heart of a human being. The method may comprise acquiring ultrasound images of the subject with a catheter comprising a position sensor. The method may also comprise capturing a plurality of 4D surface registration points in the acquired ultrasound images corresponding to points on the subject. The method may also comprise registering, in space and time, a high-resolution 4D model of the subject with the plurality of 4D surface registration points. The method may also comprise displaying high resolution, real-time images of the subject during a medical procedure based on the registration of the high resolution 4D model to the 4D surface registration points. Embodiments of the present invention are especially useful in left atrium ablation procedures.

7824399, Nov 2, 2010

Feb 16, 2006

11/355465

David E. Francischelli - Anoka MN, US
Eduardo N. Warman - Maple Grove MN, US
Rahul Mehra - Stillwater MN, US
Mark T. Stewart - Lino Lakes MN, US
James R. Skarda - Lake Elmo MN, US
Harry Puryear - Shoreview MN, US
David Schwartzman - Pittsburgh PA, US

Medtronic, Inc. - Minneapolis MN

A61B 18/18

606 34, 606 41, 600508, 607122

A system and method for creating lesions and assessing their completeness or transmurality. Assessment of transmurality of a lesion is accomplished by monitoring the depolarization signal in a local electrogram taken using electrodes located adjacent the tissue to be ablated. Following onset of application of ablation energy to heart tissue, the local electrogram is measured with electrodes located adjacent tissue to be ablated so that the ablation energy to ablation elements can be selectively reduced or terminated when transmurality is detected.

2013034, Dec 26, 2013

Jun 12, 2013

13/915974

Takeo Kanade - Pittsburgh PA, US
David Schwartzman - Pittsburgh PA, US
Hua Zhong - Pittsburgh PA, US

A61B 8/00

600424

A method and a system for producing images of a subject, such as the heart of a human being. The method may comprise acquiring ultrasound images of the subject with a catheter comprising a position sensor. The method may also comprise capturing a plurality of 4D surface registration points in the acquired ultrasound images corresponding to points on the subject. The method may also comprise registering, in space and time, a high-resolution 4D model of the subject with the plurality of 4D surface registration points. The method may also comprise displaying high resolution, real-time images of the subject during a medical procedure based on the registration of the high resolution 4D model to the 4D surface registration points. Embodiments of the present invention are especially useful in left atrium ablation procedures.

7527634, May 5, 2009

May 14, 2003

10/439280

Marco Zenati - Pittsburgh PA, US
David S. Schwartzman - Pittsburgh PA, US
Mark J. Gartner - Wexford PA, US
Daniel T. McKeel - Pittsburgh PA, US

University of Pittsburgh - Pittsburgh PA

A61B 17/08, A61B 17/24, A61B 17/22, A61B 1/00

606151, 606115, 606127, 600129

A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the LAA through various non-invasive means. After capturing the LAA with the devices and methods provided, a clamping device is preferably disposed about the base of the appendage. In certain embodiments, the appendage remains viable subsequent to the functional occlusion of the lumen.