Inventors:
Cecil Mark Eppler - Langhome PA, US
David Robert Hustead - Overland Park KS, US
Thomas Gerard Cullen - Milltown NJ, US
Raphael Johannes Zwijnenberg - Lambertville NJ, US
International Classification:
A61K 33/00, A61K 31/675, A61P 23/00
Abstract:
Provided herein are compositions, combinations, and methods comprising NMDA antagonists including, but not limited to, NMDA glutamate receptor antagonists such as [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1-(7)-en-2-yl)alkyl]phosphonic acid and derivatives thereof, which are effective in reducing the amount of anesthetic required to maintain anesthesia (i.e. to achieve an anesthetic-sparing effect).