Inventors:
David Spriggs - New York NY, US
Dharmarao Thapi - Bayside Hills NY, US
Assignee:
Memorial Sloan Kettering Cancer Center - New York NY
International Classification:
C07K 16/30
US Classification:
4241391, 5303879, 5303873, 435331, 536 2353, 436501, 435 723
Abstract:
The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to a polypeptide, or antigenic portion thereof, wherein the polypeptide is selected from a) MUC16 ectodomain polypeptide, b) MUC16 cytoplasmic domain polypeptide, and c) MUC16 extracellular domain polypeptide that contains a cysteine loop polypeptide. The invention's antibodies and compositions containing them are useful in diagnostic and therapeutic applications for diseases in which MUC16 is overexpressed, such as cancer.