DAVID R KAPLAN, MD PHD
Medical Practice at Euclid Ave, Cleveland, OH
License number
Ohio 35-051207
Category
Medical Practice
Type
Anatomic Pathology
License number
Ohio 35-051207
Category
Medical Practice
Type
Anatomic Pathology & Clinical Pathology
License number
Ohio 35-051207
Category
Medical Practice
Type
Blood Banking & Transfusion Medicine
License number
Ohio 35-051207
Category
Medical Practice
Type
Chemical Pathology
License number
Ohio 35-051207
Category
Medical Practice
Type
Clinical Pathology
License number
Ohio 35-051207
Category
Medical Practice
Type
Clinical Pathology/Laboratory Medicine
License number
Ohio 35-051207
Category
Dermatology
Type
Dermatopathology
License number
Ohio 35-051207
Category
Medical Practice
Type
Cytopathology
License number
Ohio 35-051207
Category
Medical Practice
Type
Forensic Pathology
License number
Ohio 35-051207
Category
Medical Practice
Type
Hematology
License number
Ohio 35-051207
Category
Medical Practice
Type
Immunopathology
License number
Ohio 35-051207
Category
Medical Practice
Type
Medical Microbiology
License number
Ohio 35-051207
Category
Medical Practice
Type
Molecular Genetic Pathology
License number
Ohio 35-051207
Category
Medical Practice
Type
Neuropathology
License number
Ohio 35-051207
Category
Medical Practice
Type
Pediatric Pathology
Address
Address
11100 Euclid Ave, Cleveland, OH 44106
Phone
(216) 844-7494
Professional information
Methods For Detecting An Analyte Of Interest Using Catalyzed Reporter Deposition Of Tyramide
US Patent:
6828109, Dec 7, 2004
Filed:
Dec 15, 2000
Appl. No.:
09/738049
Inventors:
David R. Kaplan - Shaker Heights OH
Assignee:
James R. Bell, Jr. - Pepper Pike OH
International Classification:
G01N 3353
US Classification:
435 71, 435 4, 435 72, 435 721, 435 78, 435 79, 435 30, 435 723, 436501, 436546, 436 63, 436 64
Abstract:
The present invention relates to methods of staining cells for flow cytometry, using catalyzed reporter deposition and amplification staining. A catalyzed reporter deposition or an analyte dependent enzyme activation system is described for detecting and/or quantitating an analyte of interest in or on a cell by flow cytometry. Also described are compositions for use in catalyzed reporter deposition methods that can be used to reduce background staining, and thereby enhance peak signal separation between histograms obtained from cells stained with control immunoglobulin versus cells stained with immunoglobulin specific for an analyte of interest, in catalyzed deposition methods.
Agent/Realtor At Nai Cummins Real Estate
Position:
Agent/REALTOR at NAI Cummins Real Estate, REALTOR at NAI Cummins (Sole Proprietorship)
Location:
Cleveland/Akron, Ohio Area
Industry:
Commercial Real Estate
Work:
NAI Cummins Real Estate
since Jul 2001
-
Agent/REALTOR
NAI Cummins
since 2001
-
REALTOR
Mail Boxes Etc.
1994 - 2002
-
Franchisee
Dillard's Department Stores
1991 - 1993
-
Manager
The Phil-Mor Men's Clothing
1981 - 1991
-
Partner
Education:
The Ohio State University 1977 - 1981
Steubenville
Steubenville
Methods For Detecting An Analyte Of Interest Using Catalyzed Reporter Deposition Of Tyramide
US Patent:
2002007, Jun 20, 2002
Filed:
Apr 13, 2001
Appl. No.:
09/835287
Inventors:
David Kaplan - Shaker Heights OH, US
International Classification:
G01N033/567, C12P021/06
US Classification:
435/007210, 435/068100
Abstract:
The present invention relates to methods of staining cells for flow cytometry, using catalyzed reporter deposition and amplification staining. A catalyzed reporter deposition or an analyte dependent enzyme activation system is described for detecting and/or quantitating an analyte of interest in a cell by flow cytometry. Also described are compositions for use in catalyzed reporter deposition methods that can be used to reduce background staining, and thereby enhance peak signal separation between histograms obtained from cells stained with control immunoglobulin versus cells stained with immunoglobulin specific for an analyte of interest, in catalyzed deposition methods.
Methods For Detecting An Analyte Of Interest Using Tyramide Coating Technology
US Patent:
6335173, Jan 1, 2002
Filed:
Jan 12, 1999
Appl. No.:
09/229001
Inventors:
David R. Kaplan - Shaker Heights OH
Assignee:
Verve, Ltd. c/o James Bell - Pepper Pike OH
International Classification:
G01N 3353
US Classification:
435 72, 435 2, 435 4, 435 723, 435 724, 435 772, 435 79, 435 4051, 435 4052, 435172, 436546, 436 63, 436 64, 436800, 436805, 436808, 436813
Abstract:
The present invention relates to methods of tyramide coating live cells for flow cytometry, using catalyzed reporter deposition and serial amplification staining. A catalyzed reporter deposition or an analyte dependent enzyme activation system is described for detecting and/or quantitating an analyte of interest on the surface of a cell by flow cytometry. Also described is a method for serial amplification staining by tyramide coating cells which possess an analyte of interest or a solid phase to which an analyte is bound.
David Ray Kaplan, Cleveland OH
Specialties:
Pathologist
Address:
11100 Euclid Ave, Cleveland, OH 44106
Method Of Enhancing Hematopoietic Cell Transplantation
US Patent:
2014000, Jan 2, 2014
Filed:
Mar 15, 2013
Appl. No.:
13/841521
Inventors:
David R. Kaplan - Shaker Heights OH, US
Assignee:
Verve, Ltd. - Pepper Pike OH
International Classification:
G01N 33/569, A61K 35/28
US Classification:
424 937, 435 721, 435 74, 435 39, 435 611
Abstract:
The invention relates to a method for enhancing the transplantation of hematopoietic cells to supplement or fully reconstitute the hematopoietic system, such as in myeloablated patients or patients otherwise deficient in hematopoietic cells. The method involves administering CD34 cells having enhanced expression of one or more of Musashi-2, PTEN, phospho-GSK-3β, Mcl-1, Atg7, phospho-Akt(ser473), HoxB4, Bmi-1, UBC13, phospho-Akt(thr308), GATA2, cMyc, and E47 at levels that provide desirable therapeutically effective amounts of self-renewal of the administered cells and desirable therapeutically effective amounts of differentiation of the administered cells into the various progeny cells of the hematopoietic system (i.e., therapeutically effective amounts of hematopoietic reconstitution). To provide such cells to a subject, the invention relates to detecting such cells prior to or during treatment to ascertain whether such cells are present in clinically-relevant amounts. It may also relate to treating a subject so as to provide clinically-relevant numbers of such cells, as with specific mobilization agents.
Cds Derivatives And Methods Of Use For Cellular Modulation And Enhancement Of Cellular Engraftment
US Patent:
5623056, Apr 22, 1997
Filed:
Dec 28, 1993
Appl. No.:
8/174583
Inventors:
Mark L. Tykocinski - Shaker Heights OH
David R. Kaplan - Cleveland Heights OH
David R. Kaplan - Cleveland Heights OH
Assignee:
TKB Associates Limited Partnership - Pepper Pike OH
International Classification:
C07K 14705, C07K 14725
US Classification:
530403
Abstract:
Specific and nonspecific immunomodulation, enhancement of cellular engraftment, and modulation of nonimmune cells are achieved by using various membrane-binding and soluble CD8 compositions.
Method Of Reducing Cellular Immune Response Involving T-Cells Using Cd8-Bearing Antigen Presenting Cells
US Patent:
5242687, Sep 7, 1993
Filed:
Apr 25, 1991
Appl. No.:
7/691475
Inventors:
Mark L. Tykocinski - Shaker Heights OH
David R. Kaplan - Cleveland Heights OH
David R. Kaplan - Cleveland Heights OH
Assignee:
TKB Associates Limited Partnership - Cleveland OH
International Classification:
A61K 7702, C07K 306
US Classification:
424 93V
Abstract:
Specific and nonspecific immunomodulation, enhancement of cellular engraftment, and modulation of nonimmune cells are achieved by using various membrane-binding and soluble CD8 compositions.
Method To Assess Patterns Of Molecular Expression
US Patent:
2014000, Jan 2, 2014
Filed:
Mar 14, 2013
Appl. No.:
13/829557
Inventors:
David R. Kaplan - Shaker Heights OH, US
International Classification:
C12N 15/10, G01N 33/53
US Classification:
506 9, 435 721, 435 71, 435 74, 435 612, 435 792
Abstract:
The invention is directed to a method to establish a biologically significant association of gene expression levels among two or more genes, the method comprising assaying a sample for expression levels of two or more genes and identifying statistically-significant associations using a correlation coefficient in the range of about 0.6 to about 1.0, wherein a correlation coefficient in that range signifies a biologically significant correlation.
Use Of Tyramide Coating And Physical Separation For Isolating Cells Or Particles Of Interest
US Patent:
6280961, Aug 28, 2001
Filed:
May 25, 1999
Appl. No.:
9/318346
Inventors:
David R. Kaplan - Shaker Heights OH
Assignee:
Verve, Ltd. - Pepper Pike OH
International Classification:
G01N 3353, G01N 33567, G01N 33566, C12Q 124
US Classification:
435 72
Abstract:
The present invention relates to methods of tyramide coating cells or particles for physical separation, using catalyzed reporter deposition and serial amplification staining. A catalyzed reporter deposition or an analyte dependent enzyme activation system is described for detecting and/or quantitating an analyte of interest on the surface of a cell by physical separation. Also described is a method for serial amplification staining by tyramide coating cells or particles which possess an analyte of interest or a solid phase to which an analyte is bound.