Inventors:
Gary Balian - Charlottesville VA
Gwo-Jaw Wang - Charlottesville VA
David Diduch - Charlottesville VA
Chang Hahn - Charlottesville VA
Assignee:
Musculoskeletal Development Enterprises, LLC - Charlottesville VA
International Classification:
A61B 1900
Abstract:
Pluripotent stem-like cells obtained from bone marrow differentiate into osteocytes, chondrocytes and adipocytes, depending on the environment encountered and treatment. If systemically administered, the cells "home", that is migrate, to bone marrow. The cells may be transformed with recombinant DNA for the expression of both reporter genes, and biological factors, such as growth factors. The cells may be systemically administered to treat osteoporosis, osteolysis, improve bone implant adherence, augment bone growth or bone repair, augment cartilage repair, augment fat production for, e. g. , breast augmentation, and the like.