DAVID Q HUANG
Architects in Cambridge, MA

5321501, Jun 14, 1994

Apr 29, 1992

7/875670

Eric A. Swanson - Acton MA
David Huang - Cambridge MA
James G. Fujimoto - Cambridge MA
Carmen A. Puliafito - Weston MA
Charles P. Lin - Somerville MA
Joel S. Schuman - Wayland MA

Massachusetts Institute of Technology - Cambridge MA

G01B 902

356345

A method and apparatus for performing optical imaging on a sample wherein longitudinal scanning or positioning in the sample is provided by either varying relative optical path lengths for an optical path leading to the sample and to a reference reflector, or by varying an optical characteristic of the output from an optical source applied to the apparatus. Transverse scanning in one or two dimensions is provided on the sample by providing controlled relative movement between the sample and a probe module in such direction and/or by steering optical radiation in the probe module to a selected transverse position. The probe module may be an external module or may be an endoscope or angioscope utilized for scanning internal channels. Multiple optical paths may be provided for parallel scanning and focus may be enhanced by varying the focal point in the sample in synchronism with longitudinal scanning of the sample.

5700688, Dec 23, 1997

Jun 7, 1995

8/488134

Raphael C. Lee - Chicago IL
David Huang - Cambridge MA

Massachusetts Institute of Technology - Cambridge MA

C12M 300, G01N 300, A61B 1756

4352871

The present invention pertains to a mechanical testing apparatus for determining the mechanical properties of an oriented tissue-equivalent, while simultaneously providing a suitable cell culture environment. The mechanical testing apparatus comprises an incubator equipped with means for controlling the atmosphere and means for controlling the temperature inside said incubator. Located within the incubator chamber are means for securing, in a desired location, the oriented tissue-equivalent to be mechanically tested. Further, the apparatus is equipped with means for controlling the length of the oriented tissue-equivalent, means for determining the force generated by the oriented tissue-equivalent, means for determining the length of the oriented tissue-equivalent and means for conditioning and recording force and length measurements.

5459570, Oct 17, 1995

Mar 16, 1993

8/033194

Eric A. Swanson - Maynard MA
David Huang - Cambridge MA
James G. Fujimoto - Cambridge MA
Carmen A. Puliafito - Weston MA
Charles P. Lin - Somerville MA
Joseph S. Schuman - Boston MA

Massachusetts Institute of Technology - Cambridge MA

G01D 902

356345

A method and apparatus for performing various optical measurements is provided utilizing an optical coherence domain refrectometer (OCDR). A short coherence optical radiation source applies optical radiation through like optical paths to a sample and an optical reflector. The optical reflector is movable in accordance with a predetermined velocity profile to permit interferometric scanning of the sample, the resulting output having a Doppler shift frequency modulation. This output may be demodulated and detected to obtain desired measurements and other information. Additional information may be obtained by applying radiation from two or more sources at different wavelengths to the sample and reflector and by separately demodulating the resulting outputs before processing. Birefringent information may be obtained by polarizing the optical radiation used, by suitably modifying the polarization in the sample and reference paths and by dividing the output into orthogonal polarization outputs which are separately demodulated before processing.

5521087, May 28, 1996

Jan 9, 1995

8/370555

Raphael C. Lee - Chicago IL
David Huang - Cambridge MA

Massachusetts Institute of Technology - Cambridge MA

A61F 206, A61F 208, A61F 210, C12N 502

4352402

The present invention pertains to an oriented tissue-equivalent formed by contracting a collagen solution with connective tissue cells. In the method of the present invention, the contraction of collagen fibrils by the connective tissue cells is restrained along an axis of cell alignment defined by at least two structural members within the gel, whereby the connective tissue cells align along the axis thereby producing an oriented tissue-equivalent. In a preferred embodiment fibroblast cells are used to contract a collagen gel to form connective tissue into a ligament configuration.

5756350, May 26, 1998

Jun 7, 1995

8/477993

Raphael C. Lee - Chicago IL
David Huang - Cambridge MA

Massachusetts Institute of Technology - Cambridge MA

C12N 500

435325

The present invention pertains to an oriented tissue-equivalent formed by contracting a collagen solution with connective tissue cells. In the method of the present invention, the contraction of collagen fibrils by the connective tissue cells is restrained along an axis of cell alignment defined by at least two structural members within the gel, whereby the connective tissue cells align along the axis thereby producing an oriented tissue-equivalent.