Inventors:
Athena Soulika - Sacramento CA, US
David Pleasure - Sacramento CA, US
International Classification:
A61K 39/395, A61K 31/47, A61K 31/517, A61K 31/55, A61K 31/44, A61K 31/7088, A61K 31/551, A61P 33/10, A61P 33/02, A61P 31/12, A61P 25/00, A61P 37/06, A61K 38/17, A61K 31/135
US Classification:
4241721, 514 177, 514311, 5142661, 514217, 514656, 514324, 51421402, 514 44 A
Abstract:
The present invention is directed to the identification of novel mechanisms involved in the initiation and spreading of axonal degeneration. In particular, the instant invention relates to the identification of a relationship between Toll-Like Receptors (TLRs) and axonal degeneration and the use of TLR inhibitors as antagonists of axonal degeneration.