Inventors:
Kevan M. Shokat - San Francisco CA, US
David Fruman - Irvine CA, US
Pingda Ren - San Diego CA, US
Troy Edward Wilson - San Marino CA, US
Liansheng Li - San Diego CA, US
Andrew Hsieh - San Francisco CA, US
Morris Feldman - San Francisco CA, US
Beth Apsel - San Francisco CA, US
Yi Liu - San Diego CA, US
Christian Rommel - La Jolla CA, US
Katrina Chan - San Diego CA, US
Davide Ruggero - San Francisco CA, US
David Pearce - San Francisco CA, US
Matthew Janes - Altadena CA, US
Assignee:
The Regents of the University of California, a California corporation - Oakland CA
Intellikine, Inc. - La Jolla CA
International Classification:
A61K 31/506, C12N 5/09, C12N 9/99, A61K 31/519, A61K 31/436, A61P 35/00, A61P 13/12, A61P 9/12, A61P 9/04, A61P 1/16
US Classification:
51425218, 435375, 435184, 5142621, 514291
Abstract:
The present invention provides methods and compositions for selective modulation of certain protein kinases, and especially mTor complexes. The methods and compositions are particularly useful in inhibiting mTor selectively for therapeutic applications.