Inventors:
Yoram Vodovotz - Sewickley PA, US
Gregory Constantine - Baden PA, US
Jorg Christian Gerlach - Pittsburgh PA, US
Qi Mi - Pittsburgh PA, US
Maxim Mikheev - Clairton PA, US
David Okonkwo - Pittsburgh PA, US
Alexey Solovyev - Pittsburgh PA, US
International Classification:
A61M 1/34, C12M 3/00
US Classification:
604 609, 4352891, 4352971
Abstract:
A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.