Inventors:
Jack Nguyen - San Francisco CA, US
Gregory T. Went - Mill Valley CA, US
Paul Spence - Mill CA, US
Timothy J. Fultz - Pleasant Hill CA, US
David Chernoff - San Rafael CA, US
Terry L. Burkoth - Palo Alto CA, US
Rowan Chapman - Burlingame CA, US
Mickey S. Urdea - Alamo CA, US
Assignee:
Adamas Pharmaceuticals, Inc. - Emeryville CA
International Classification:
A61K 31/7056, A61K 31/351, A61K 31/215, A61K 31/196, A61K 31/195, A61K 31/131, C07H 19/056, C07D 309/28, C07C 69/75, C07C 61/22, C07C 229/48, C07C 211/38
US Classification:
514529, 514629, 514 43, 514659, 514661, 514662, 514459, 514563, 536 287, 549424, 560128, 562507, 564456, 564458, 564459
Abstract:
Kits comprising an M2 inhibitor selected from amantadine and rimantadine; ribavirin, and a neuraminidase inhibitor (NAi) in an amount that is antivirally effective in the combination, an oral dosage form containing 75-250 mg of the M2 inhibitor, an oral dosage form comprising 100-400 mg of ribavirin and a neuraminidase inhibitor are provided for the treatment of influenza. Some embodiments of the kits comprise an oral dosage form containing 75-250 mg of the M2 inhibitor, an oral dosage form comprising 100-400 mg of ribavirin, and a neuraminidase inhibitor.