Inventors:
Gary H. Posner - Baltimore MD, US
Lauren E. Woodard - Baltimore MD, US
David R. Levine - Baltimore MD, US
Deuk Kyu Moon - Baltimore MD, US
Bryan T. Mott - Baltimore MD, US
Assignee:
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
A61K 31/4433, C07D 493/18, A61K 31/357, A61K 31/695, A61P 31/00, A61P 33/00, A61P 33/06, A61K 31/4706, A61K 31/4709, A61P 25/18, A61K 31/5415, A61K 31/451, A61K 31/496, A61K 31/5513, A61K 31/519, A61K 31/554, A61P 35/00, A61P 35/02, C07D 405/14
US Classification:
514 63, 5462824, 514338, 549348, 514450, 514313, 514305, 514314, 5142262, 514327, 5142258, 51425213, 5142255, 514220, 51425941, 51421113, 51425404, 51425307
Abstract:
Monomeric and dimeric trioxane fluoroaryl amides, 5-carbon-linked, C-10 non-acetal trioxane dimer esters; trioxane silylamides; and trioxane dimer orthoesters and methods of their use for treating subjects infected with malaria or other parasitic infectious diseases including, but not limited to, toxoplasmic infection; subjects afflicted with psychiatric conditions associated with toxoplasmic infection; and subjects afflicted with cancer.