Inventors:
Jay A. Berzofsky - Bethesda MD
Mutsunori Shirai - Rockville MD
C. David Pendleton - Bethesda MD
Steven Kozlowski - Washington DC
David H. Margulies - Bethesda MD
Assignee:
The United States of America as represented by the Department of Health
and Human Services - Washington DC
International Classification:
A61K 3921, A61K 3938, A61K 3912, C12N 1500
Abstract:
Peptides having high activity in the eliciting of a cytotoxic T lymphocyte response to the HIV-1 envelope glycoprotein gpl60 are described. The activation of 12-15 residue peptides by proteolytic degradation to shorter peptides is shown as are general techniques for characterizing such activation processes.