Inventors:
Eberhard F. Gottwald - Bovenden, DE
Hermann P. Osterwald - Bovenden, DE
Horst M. Machoczek - Gleichen, DE
David Mayron - Blue Bell PA
Assignee:
Smith Kline Dauelsberg GmbH - Gottingen
International Classification:
A61K 928
Abstract:
The present invention provides a pharmaceutical granule composition comprising cimetidine and, as a granulating agent and taste-masking agent, an ester of a polyhydroxy compound, and where desired a palatable pharmaceutically acceptable emulsifier. Particular esters are glycerol esters. The granules of the present invention can be used in the preparation of chewable tablets which have good palatability and bioavailability.