Inventors:
David Anderson - Ashland VA, US
Vince Conklin - Glen Allen VA, US
Benjamin Cameransi - Georgetown SC, US
David M. Kleinman - Rochester NY, US
Eugene R. Cooper - Berwyn PA, US
International Classification:
A61K 9/10, A61K 9/00, A61K 38/13, A61K 39/00, A61K 31/573, A61K 31/445, A61K 39/395, A61K 31/685, A61K 31/355, A61K 9/14, A61P 37/06, A61P 29/00, A61P 27/02, B82Y 5/00
US Classification:
424484, 424400, 514 205, 4241841, 514180, 514330, 4241411, 514 78, 514458, 424489, 977906
Abstract:
The eye is effectively treated by providing it with formulations including uncoated cationically charged microparticles of reversed cubic phase or reversed hexagonal phase material. The treatment methods are effective; for a variety of diseases and conditions including dry eye. The structure, charge and components of the microparticles in dispersion, with or without an active ingredient, provide mucoadhesion, layering, protection and prolonged duration of ophthalmic action.