DAVID MARK ROTHSTEIN
Medical Practice in Pittsburgh, PA
License number
Pennsylvania MD026554E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Pittsburgh, PA 15261
Personal information
See more information about DAVID MARK ROTHSTEIN at radaris.comName
Address
Phone
400 N Buckstown Rd, Langhorne, PA 19047
942 Hill St, Manheim, PA 17545
8 Pin Oak Ct, Lafayette Hl, PA 19444
6 Doe Run, Thornton, PA 19373
66 Aldham Rd, Phoenixville, PA 19460
Professional information
Regulatory B Cells And Their Use
US Patent:
2012005, Mar 1, 2012
Filed:
Aug 31, 2011
Appl. No.:
13/223169
Inventors:
David Rothstein - Pittsburgh PA, US
Qing Ding - Pittsburgh PA, US
Qing Ding - Pittsburgh PA, US
International Classification:
A61K 39/395, A61K 35/12, G01N 33/53, A61P 35/00, C12Q 1/02, C12N 5/0781, A61P 37/02
US Classification:
4241311, 435326, 424 9371, 435 29, 435 71
Abstract:
Isolated regulatory B cells are disclosed, and compositions including these isolated regulatory B cells. The isolated regulatory B cells are mammalian and express T cell immunoglobulin mucin-1 (TIM-1). In some embodiments the regulatory B cells produce IL-10. Methods for treating a subject with an immune-mediated disorder are disclosed. These methods include administering to the subject a therapeutically effective amount of a composition including regulatory B cells, thereby treating the immune mediated disorder in the subject. Methods are also disclosed for treating a subject with an immune-mediated disorder, wherein the methods include administering to the subject a therapeutically effective amount of an antibody that specifically binds TIM-1, wherein the antibody is activates TIM-1CD19 B cells. Methods are also disclosed for assessing the immune status of a subject.