Inventors:
David M. Nierman - New York NY
Thomas H. Kalb - Scarsdale NY
International Classification:
C12Q 102, C12Q 100, C12M 134, G01N 3349
Abstract:
The present invention relates to a method of determining the metabolic state of neutrophils present in the body of a patient. In particular, the present invention involves the measurement of the rates of in vitro glycolysis in blood samples taken from individuals as a function of the number of selected cells present in the blood sample, including neutrophils and red blood cells. The physiologic information provided by the present method, which, for example, indicates whether an individual's neutrophils are in a quiescent, primed or activated state, allows the medical practitioner to attain a better understanding of the patient's condition and, consequently, assists in the diagnosis and formulation of proper treatment.