DAVID M KRISKY
Medical Practice in Sewickley, PA
License number
Pennsylvania MD419559
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Sewickley, PA 15143
Personal information
See more information about DAVID M KRISKY at radaris.comName
Address
Phone
1551 Field Club Dr, Pittsburgh, PA 15237
1614 Settlers Dr, Sewickley, PA 15143
121 Meyran Ave #B, Pittsburgh, PA 15213
1551 Field Club Dr, Pittsburgh, PA 15237
1614 Settlers Dr, Sewickley, PA 15143
Professional information
Dr. David M Krisky, Sewickley PA - MD (Doctor of Medicine)
Specialties:
Anatomic & Clinical Pathology
Address:
1614 Settlers Dr, Sewickley 15143
Languages:
English
Education:
Medical School
University of Pittsburgh / Main Campus
Graduated: 1995
University of Pittsburgh / Main Campus
Graduated: 1995
Peripherally Delivered Glutamic Acid Decarboxylase Gene Therapy For Spinal Cord Injury Pain
US Patent:
2007020, Sep 6, 2007
Filed:
Oct 28, 2005
Appl. No.:
11/261389
Inventors:
Joseph Glorioso - Blawnox PA, US
David Fink - Ann Arbor MI, US
Darren Wolfe - Verona PA, US
David Krisky - Sewickley PA, US
David Fink - Ann Arbor MI, US
Darren Wolfe - Verona PA, US
David Krisky - Sewickley PA, US
Assignee:
University of Pittsburgh of the Commonwealth System of Higher Education - Pittsburgh PA
Department of Veterans Affairs (024) - Washington DC
Department of Veterans Affairs (024) - Washington DC
International Classification:
A61K 48/00, C12N 15/86
US Classification:
424093200, 514044000, 435456000, 435325000
Abstract:
The invention provides a vector, preferably a herpes simplex virus (HSV) vector, comprising a polynucleotide sequence encoding a glutamic acid decarboxylase (GAD) protein. The invention also provides a stock of such vectors and a pharmaceutical composition comprising such vectors. The invention further provides a method of treating pain, such as spinal cord injury pain, in a mammal comprising administering to a mammal a vector comprising a nucleotide sequence encoding a glutamic acid decarboxylase (GAD) protein in an amount effective to treat spinal cord injury pain.
Targeted Delivery Of Glycine Receptors To Excitable Cells
US Patent:
2008028, Nov 20, 2008
Filed:
May 14, 2008
Appl. No.:
12/152310
Inventors:
Michael Cascio - Pittsburgh PA, US
James R. Goss - Bethel Park PA, US
David Krisky - Sewickley PA, US
James R. Goss - Bethel Park PA, US
David Krisky - Sewickley PA, US
Assignee:
University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
A01K 67/027, C12N 5/06, A61P 25/02, A61K 31/7088
US Classification:
800 18, 435375, 514 44
Abstract:
The invention provides a method of modulating electrophysiological activity of an excitable cell. The method involves causing exogenous expression of a glycine receptor (GlyR) protein in an excitable cell of a subject. Thereafter, the excitable cell is exposed to an allosteric modulator of the GlyR protein. Modulation of the exogenous GlyR protein (an ion channel) in response to the allosteric modulator modulates the electrophysiological activity of the excitable cell. The method can be used to control pain in a subject. The invention further provides a replication-defective HSV vector comprising an expression cassette encoding a GlyR protein, stocks and pharmaceutical compositions containing such vectors, and a transgenic animal.
Targeted Delivery Of Glycine Receptors To Excitable Cells
US Patent:
2011021, Sep 1, 2011
Filed:
Mar 8, 2011
Appl. No.:
13/043195
Inventors:
Michael Cascio - Pittsburgh PA, US
James R. Goss - Bethel Park PA, US
David Krisky - Sewickley PA, US
James R. Goss - Bethel Park PA, US
David Krisky - Sewickley PA, US
Assignee:
University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
A61K 48/00, A61P 25/00, A61P 29/00
US Classification:
514 44 R
Abstract:
The invention provides a method of modulating electrophysiological activity of an excitable cell. The method involves causing exogenous expression of a glycine receptor (GlyR) protein in an excitable cell of a subject. Thereafter, the excitable cell is exposed to an allosteric modulator of the GlyR protein. Modulation of the exogenous GlyR protein (an ion channel) in response to the allosteric modulator modulates the electrophysiological activity of the excitable cell. The method can be used to control pain in a subject. The invention further provides a replication-defective HSV vector comprising an expression cassette encoding a GlyR protein, stocks and pharmaceutical compositions containing such vectors, and a transgenic animal.
Herpes Simplex Virus Vector
US Patent:
7531167, May 12, 2009
Filed:
Mar 30, 2007
Appl. No.:
11/694118
Inventors:
Joseph C. Glorioso - Blawnox PA, US
Darren Wolfe - Verona AZ, US
David Krisky - Sewickley PA, US
Darren Wolfe - Verona AZ, US
David Krisky - Sewickley PA, US
Assignee:
University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
A01N 63/00, A61K 48/00
US Classification:
424 932, 424 9321
Abstract:
The invention provides a herpes simplex virus vector comprising deletions in ICP4, ICP27, and UL55.
Cell Line
US Patent:
8148146, Apr 3, 2012
Filed:
Apr 3, 2009
Appl. No.:
12/418062
Inventors:
Joseph C. Glorioso - Blawnox PA, US
Darren Wolfe - Verona PA, US
David Krisky - Sewickley PA, US
Darren Wolfe - Verona PA, US
David Krisky - Sewickley PA, US
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
C12N 5/00, C12N 15/00
US Classification:
435325, 435455
Abstract:
The invention provides a cell line complementing HSV ICP4, ICP27, and UL55 genes.
Cell Line
US Patent:
8309349, Nov 13, 2012
Filed:
Apr 3, 2009
Appl. No.:
12/418062
Inventors:
Joseph C. Glorioso - Blawnox PA, US
Darren Wolfe - Verona PA, US
David Krisky - Sewickley PA, US
Darren Wolfe - Verona PA, US
David Krisky - Sewickley PA, US
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
C12N 5/00, C12N 15/00
US Classification:
435325, 435455
Abstract:
The invention provides a cell line complementing HSV ICP4, ICP27, and UL55 genes.