DAVID M KOELLE
Osteopathic Medicine at Roosevelt Way, Seattle, WA
License number
Washington MD00025305
Category
Osteopathic Medicine
Type
Infectious Disease
Address
Address
4245 Roosevelt Way NE, Seattle, WA 98105
Phone
(206) 598-8750
(206) 543-6420
(206) 543-6420
Personal information
See more information about DAVID M KOELLE at radaris.comName
Address
Phone
4748 34Th Ave NE, Seattle, WA 98105
3338 162Nd St, Bellevue, WA 98008
4748 34Th Ave NE, Seattle, WA 98105
Organization information
See more information about DAVID M KOELLE at bizstanding.comDavid M Koelle MD
1100 Fairview Ave N, Seattle, WA 98109
Categories:
Oncology Physicians & Surgeons
Phone:
(206) 667-4324 (Phone)
Professional information
See more information about DAVID M KOELLE at trustoria.com
Dr. David M Koelle, Seattle WA - MD (Doctor of Medicine)
Dr. David M Koelle, Seattle WA - MD (Doctor of Medicine)
Specialties:
Infectious Disease Medicine
Address:
UNIVERSITY OF WASHINGTON
1959 NE Pacific St, Seattle 98195
(206) 598-3300 (Phone), (206) 598-6611 (Fax)
UNIVERSITY OF WASHINGTON
1959 NE Pacific St, Seattle 98195
(206) 598-5637 (Phone), (206) 598-4303 (Fax)
UNIVERSITY OF WASHINGTON
1959 NE Pacific St, Seattle 98195
(206) 598-3300 (Phone), (206) 667-6643 (Fax)
University Of Washington
1959 NE Pacific St, Seattle 98195
(206) 598-3300 (Phone), (206) 667-6643 (Fax)
750 Republican St SUITE 651, Seattle 98109
1959 NE Pacific St, Seattle 98195
(206) 598-3300 (Phone), (206) 598-6611 (Fax)
UNIVERSITY OF WASHINGTON
1959 NE Pacific St, Seattle 98195
(206) 598-5637 (Phone), (206) 598-4303 (Fax)
UNIVERSITY OF WASHINGTON
1959 NE Pacific St, Seattle 98195
(206) 598-3300 (Phone), (206) 667-6643 (Fax)
University Of Washington
1959 NE Pacific St, Seattle 98195
(206) 598-3300 (Phone), (206) 667-6643 (Fax)
750 Republican St SUITE 651, Seattle 98109
Certifications:
Infectious Disease, 1992, Internal Medicine, 1988
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
UNIVERSITY OF WASHINGTON
1959 NE Pacific St, Seattle 98195
750 Republican St SUITE 651, Seattle 98109
UNIVERSITY OF WASHINGTON
1959 NE Pacific St, Seattle 98195
University Of Washington
1959 NE Pacific St, Seattle 98195
UNIVERSITY OF WASHINGTON
1959 NE Pacific St, Seattle 98195
Harborview Medical Center
325 9Th Ave, Seattle 98104
University of Washington Medical Center
1959 East Pacific St, Seattle 98195
1959 NE Pacific St, Seattle 98195
750 Republican St SUITE 651, Seattle 98109
UNIVERSITY OF WASHINGTON
1959 NE Pacific St, Seattle 98195
University Of Washington
1959 NE Pacific St, Seattle 98195
UNIVERSITY OF WASHINGTON
1959 NE Pacific St, Seattle 98195
Harborview Medical Center
325 9Th Ave, Seattle 98104
University of Washington Medical Center
1959 East Pacific St, Seattle 98195
Education:
Medical School
Univ Of Wa Sch Of Med
Graduated: 1985
Beth Israel Deaconess Medical Center
University of Washington
Univ Of Wa Sch Of Med
Graduated: 1985
Beth Israel Deaconess Medical Center
University of Washington
Immunological Herpes Simplex Virus Antigens And Methods For Use Thereof
Immunological Herpes Simplex Virus Antigens And Methods For Use Thereof
US Patent:
6375952, Apr 23, 2002
Filed:
Aug 5, 1999
Appl. No.:
09/368770
Inventors:
David M. Koelle - Seattle WA
Lawrence Corey - Seattle WA
Lawrence Corey - Seattle WA
Assignee:
University of Washington - Seattle WA
International Classification:
A61K 39245
US Classification:
4241861, 4241921, 4241991, 4242311, 536 234, 536 237, 530350, 435 693, 435 697, 4352351, 4352523, 4353201, 435325
Abstract:
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by T-cells derived from herpetic lesions or from uterine cervix. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
Rapid, Efficient Purification Of Hsv-Specific T-Lymphocytes And Hsv Antigens Identified Via Same
Rapid, Efficient Purification Of Hsv-Specific T-Lymphocytes And Hsv Antigens Identified Via Same
US Patent:
7431934, Oct 7, 2008
Filed:
Feb 28, 2006
Appl. No.:
11/364438
Inventors:
David M. Koelle - Seattle WA, US
Zhi Liu - Seattle WA, US
Lawrence Corey - Mercer Island WA, US
Zhi Liu - Seattle WA, US
Lawrence Corey - Mercer Island WA, US
Assignee:
University of Washington - Seattle WA
International Classification:
A61K 39/12
US Classification:
4242291, 435 6
Abstract:
Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
Rapid, Efficient Purification Of Hsv-Specific T-Lymphocytes And Hsv Antigens Identified Via Same
Rapid, Efficient Purification Of Hsv-Specific T-Lymphocytes And Hsv Antigens Identified Via Same
US Patent:
8197824, Jun 12, 2012
Filed:
Jan 21, 2010
Appl. No.:
12/691309
Inventors:
David M. Koelle - Seattle WA, US
Zhi Liu - Seattle WA, US
Lawrence Corey - Mercer Island WA, US
Zhi Liu - Seattle WA, US
Lawrence Corey - Mercer Island WA, US
Assignee:
University of Washington - Seattle WA
International Classification:
A61K 39/245
US Classification:
4242311, 4242041, 435 5, 435 911
Abstract:
Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigen or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
Immunological Herpes Simplex Virus Antigens And Methods For Use Thereof
Immunological Herpes Simplex Virus Antigens And Methods For Use Thereof
US Patent:
2012002, Feb 2, 2012
Filed:
Oct 18, 2011
Appl. No.:
13/276166
Inventors:
David M. Koelle - Seattle WA, US
Lawrence Corey - Mercer Island WA, US
Lawrence Corey - Mercer Island WA, US
Assignee:
University of Washington - Seattle WA
International Classification:
A61K 39/245, A61K 35/76, C12P 21/06, C12N 7/01, C12N 1/21, C12N 15/63, C07K 14/03, C07K 7/08, C07K 14/035, C07H 21/04, A61K 47/00, C12N 5/02
US Classification:
4241861, 4242311, 424 932, 435 691, 435 697, 4352351, 435375, 4353201, 530324, 530326, 530327, 530350, 536 234, 4352523
Abstract:
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by T-cells derived from herpetic lesions or from uterine cervix. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
Compositions And Methods For Vaccinating Against Hsv-2
Compositions And Methods For Vaccinating Against Hsv-2
US Patent:
2012032, Dec 27, 2012
Filed:
Aug 14, 2012
Appl. No.:
13/585668
Inventors:
Adrian VILALTA - San Diego CA, US
Michal Margalith - Solana Beach CA, US
Lichun Dong - Seattle WA, US
David M. Koelle - Seattle WA, US
Michal Margalith - Solana Beach CA, US
Lichun Dong - Seattle WA, US
David M. Koelle - Seattle WA, US
Assignee:
THE UNIVERSITY OF WASHINGTON - Seattle WA
Vical Incorporated - San Diego CA
Vical Incorporated - San Diego CA
International Classification:
A61K 39/245, A61P 31/22, C07K 14/035, C12N 15/38, C12N 15/62
US Classification:
4242311, 536 2372, 536 234, 530350
Abstract:
This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method.
Compositions And Methods For Vaccinating Against Hsv-2
Compositions And Methods For Vaccinating Against Hsv-2
US Patent:
8263087, Sep 11, 2012
Filed:
Oct 23, 2009
Appl. No.:
12/604694
Inventors:
Adrian Vilalta - San Diego CA, US
Michal Margalith - Solana Beach CA, US
Lichun Dong - Seattle WA, US
David M. Koelle - Seattle WA, US
Michal Margalith - Solana Beach CA, US
Lichun Dong - Seattle WA, US
David M. Koelle - Seattle WA, US
Assignee:
Vical Incorporated - San Diego CA
The University of Washington - Seattle WA
The University of Washington - Seattle WA
International Classification:
A61K 39/245
US Classification:
4242311, 4242041, 435 911
Abstract:
This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method.
Compositions And Methods For Vaccinating Against Hsv-2
Compositions And Methods For Vaccinating Against Hsv-2
US Patent:
7628993, Dec 8, 2009
Filed:
Jul 20, 2007
Appl. No.:
11/781153
Inventors:
Adrian Vilalta - San Diego CA, US
Michal Margalith - Solana Beach CA, US
Lichun Dong - Seattle WA, US
David M. Koelle - Seattle WA, US
Michal Margalith - Solana Beach CA, US
Lichun Dong - Seattle WA, US
David M. Koelle - Seattle WA, US
Assignee:
Vical Incorporated - San Diego CA
University of Washington - Seattle WA
University of Washington - Seattle WA
International Classification:
A61K 39/245
US Classification:
4242311, 435 6
Abstract:
This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method.
Compositions And Methods For Vaccinating Against Hsv-2
Compositions And Methods For Vaccinating Against Hsv-2
US Patent:
2012032, Dec 27, 2012
Filed:
Aug 9, 2012
Appl. No.:
13/571247
Inventors:
Adrian Vilalta - San Diego CA, US
Michal Margalith - Solana Beach CA, US
Lichun Dong - Seattle WA, US
David M. Koelle - Seattle WA, US
Michal Margalith - Solana Beach CA, US
Lichun Dong - Seattle WA, US
David M. Koelle - Seattle WA, US
Assignee:
THE UNIVERSITY OF WASHINGTON - SEATTLE WA
Vical Incorporated - San Diego CA
Vical Incorporated - San Diego CA
International Classification:
A61K 31/711, A61P 37/04, A61P 31/22
US Classification:
4242311
Abstract:
This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method.
Hsv-1 Epitopes And Methods For Using Same
Hsv-1 Epitopes And Methods For Using Same
US Patent:
2013030, Nov 21, 2013
Filed:
May 10, 2013
Appl. No.:
13/892185
Inventors:
University of Washington - , US
DAVID M. KOELLE - Seattle WA, US
DAVID M. KOELLE - Seattle WA, US
Assignee:
University of Washington - Seattle WA
International Classification:
C07K 14/005
US Classification:
4241861, 4242311, 530350, 4352351, 424 936, 435375, 424 937, 435236
Abstract:
The invention provides HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.