DR. DAVID M BROWN, M.D.
Medical Practice at Outer 40 Rd, Wildwood, MO

6388132, May 14, 2002

Oct 24, 2000

09/694783

Daniel P Getman - Chesterfield MO
Gary A DeCrescenzo - St. Peters MO
John N Freskos - Clayton MO
Michael L Vazquez - Ballwin MO
James A Sikorski - Des Peres MO
Balekudru Devadas - Chesterfield MO
Srinivasan Raj Nagarajan - Chesterfield MO
David L Brown - Chesterfield MO
Joseph J McDonald - Ballwin MO

G. D. Searle Co. - Chicago IL

C07C31103

564 92, 564 90, 514604

Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

5633272, May 27, 1997

Jun 7, 1995

8/473884

John J. Talley - Brentwood MO
David L. Brown - Chesterfield MO
Srinivasan Nagarajan - Chesterfield MO
Jeffery S. Carter - Chesterfield MO
Richard M. Weier - Lake Bluff IL
Michael A. Stealey - Libertyville IL
Paul W. Collins - Deerfield IL
Roland S. Rogers - late of Richmond Heights MO
Karen Seibert - St. Louis MO

C07D26106, C07D26110, C07D26112, C07D26114, A61K 3142

514378

A class of substituted isoxazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II ##STR1## wherein R. sup. 1 is selected from hydroxyl, lower alkyl, carboxyl, lower carboxyalkyl, lower aminocarbonylalkyl, lower alkoxycarbonylalkyl, lower aralkyl, lower alkoxyalkyl, lower aralkoxyalkyl, lower alkylthioalkyl, lower aralkylthioalkyl, lower alkylaminoalkyl, lower aryloxyalkyl, lower arylthioalkyl, lower haloalkyl, lower hydroxylalkyl, cycloalkyl, cycloalkylalkyl, and aralkyl; wherein R. sup. 3 is selected from cycloalkyl, cycloalkenyl, aryl, and heteroaryl; wherein R. sup. 3 is optionally substituted at a substitutable position with one or more radicals independently selected from lower alkylsulfinyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, lower haloalkyl, hydroxyl, lower hydroxyalkyl, lower haloalkoxy, amino, lower alkylamino, lower arylamino, lower aminoalkyl, nitro, halo, lower alkoxy, aminosulfonyl, and lower alkylthio; and wherein R. sup. 4 is selected from lower alkyl, hydroxyl and amino; or a pharmaceutically-acceptable salt thereof.

5965601, Oct 12, 1999

Mar 3, 1998

9/033897

Daniel P Getman - Chesterfield MO
Gary A DeCrescenzo - St. Peters MO
John N Freskos - Clayton MO
Michael L Vazquez - Gurnee IL
James A Sikorski - Des Peres MO
Balekudru Devadas - Chesterfield MO
Srinivasan Nagarajan - Chesterfield MO
David L Brown - Chesterfield MO
Joseph J McDonald - Ballwin MO

G. D. Searle & Co. - Chicago IL

A61K 3140, C07D20706

514422

Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

5968970, Oct 19, 1999

Jan 2, 1998

8/894900

Daniel P. Getman - Chesterfield MO
Gary A. DeCrescenzo - St. Peter MO
John N. Freskos - Clayton MO
Michael L. Vazquez - Ballwin MO
James A. Sikorski - Des Peres MO
Balekudru Devadas - Chesterfield MO
Srinivasan R. Nagarajan - Chesterfield MO
David L. Brown - Chesterfield MO
Joseph J. McDonald - Ballwin MO

G. D. Searle & Company - Chicago IL

A61K 3140, C07D20706

514422

Described herein is a retroviral protease inhibiting compound of the formula: ##STR1## or a pharmaceutically acceptable salt, prodrug or ester thereof.

2014003, Feb 6, 2014

Jul 2, 2013

13/933616

Charles Richard Graham - St. Peters MO, US
David Louis Brown - Chesterfield MO, US

C07D 413/04

548131

Provided herein are processes for the preparation of 3,5-disubstituted-1,2,4-oxadiazoles and salts thereof comprising reacting a N-hydroxyamidine with an acyl chloride in a reaction mixture comprising a water-immiscible organic solvent and an aqueous base at relatively low reaction temperatures.

5756533, May 26, 1998

Jun 7, 1995

8/474052

Daniel P. Getman - Chesterfield MO
Gary A. DeCrescenzo - St. Peters MO
John N. Freskos - Clayton MO
Michael L. Vazquez - Gurnee IL
James A. Sikorski - Des Peres MO
Balekudru Devadas - Chestefield MO
Srinivasan Nagarajan - Chesterfield MO
David L. Brown - Chesterfield MO
Joseph J. McDonald - Ballwin MO

G.D. Searle & Co. - Skokie IL

A61K 3140, C07D20706

514422

Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

6172101, Jan 9, 2001

Apr 23, 1998

8/894984

Daniel P. Getman - Chesterfield MO
Gary A. De Crescenzo - St. Charles MO
John N. Freskos - Clayton MO
Michael L. Vazquez - Gurnee IL
James A. Sikorski - Des Peres MO
Srinivasan Nagarajan - Chesterfield MO
David L. Brown - Chesterfield MO
Joseph J. McDonald - Ballwin MO

G. D. Searle & Co. - Chicago IL

A61K 314025, C07D40512

514422

Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

6214861, Apr 10, 2001

Feb 9, 2000

9/501265

Daniel P Getman - Chesterfield MO
Gary A DeCrescenzo - St. Peters MO
John N Freskos - Clayton MO
Michael L Vazquez - Gurnee IL
James A Sikorski - De Peres MO
Balekudru Devadas - Chesterfield MO
Srinivasan Nagarajan - Chesterfield MO
David L Brown - Chesterfield MO
Joseph J McDonald - Ballwin MO

G.D. Searle & Co. - Skokie IL

A61K 314025, A61K 31401, C07D20709

514422

Selected heterocycle carbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

2003003, Feb 13, 2003

Apr 16, 2002

10/124209

David Brown - Chesterfield MO, US
Matthew Graneto - Chesterfield MO, US
Cindy Ludwig - St. Louis MO, US
John Molyneaux - St. Louis MO, US
John Talley - St. Louis MO, US

Pharmacia Corporation

A61K031/4439, A61K031/44, A61K031/40, A61K031/277, C07C317/32

514/336000, 514/357000, 514/408000, 514/520000, 514/602000, 514/709000, 546/268100, 546/339000, 546/329000, 546/330000, 548/577000, 558/413000, 564/084000, 564/085000, 564/086000, 568/028000, 568/029000

Methods of treating cyclooxygenase-2 mediated disorders comprising administering to a subject a therapeutically effective amount of one or more fluoro-substituted benzenesulfonyl compounds corresponding to Formula I: wherein A, X, n, R, R, and Rare as described in the specification, and novel fluoro-substituted benzenesulfonyl compounds within Formula I.