Inventors:
Carl H. June - Merion Station PA, US
Bruce L. Levine - Cherry Hill NJ, US
David L. Porter - Springfield PA, US
Michael D. Kalos - Philadelphia PA, US
Michael C. Milone - Cherry Hill NJ, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A61K 35/14
US Classification:
424 9321, 536 234, 5303873, 435328, 4353201
Abstract:
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.