DAVID L STEED
Medical Practice in Pittsburgh, PA

8642547, Feb 4, 2014

Jan 7, 2012

13/374674

George L. Sing - New York NY, US
David L. Steed - Pittsburgh PA, US

Stemnion, Inc. - Pittsburgh PA

A61K 38/18

514 94

The invention is directed to methods for accelerating the healing of connective tissue injuries and disorders. In particular, the invention is directed to accelerating the healing of injuries and disorders of tendons and ligaments. Such methods utilize novel compositions including, but not limited to, extraembryonic cytokine-secreting cells (herein referred to as ECS cells), including, but not limited to, Amnion-derived Multipotent Progenitor cells (herein referred to as AMP cells) and conditioned media derived therefrom (herein referred to as Amnion-derived Cellular Cytokine Solution or ACCS), including pooled ACCS, and Physiologic Cytokine Solution (PCS).

8642027, Feb 4, 2014

Aug 25, 2011

13/199291

Richard A. Banas - Turtle Creek PA, US
David L. Steed - Pittsburgh PA, US
Randall G. Rupp - Swanton VT, US

Stemnion, Inc. - Pittsburgh PA

A61K 45/00

424 931, 4242781

The invention is directed to methods of modulating ischemic injury in tissues and organs. The invention is further directed to methods of increasing time to ischemic injury in tissues and organs. Such methods utilize compositions comprising cells capable of modulating inflammatory responses, referred to herein as Inflammatory Response Modulating Cells (IRMCs). The IRMCs any be used directly or cell membranes derived from them may be used in practicing the methods of the invention. In addition, the IRMCs and IRMC membranes may be used alone or in combination with each other and/or in combination with various suitable active agents.

8630810, Jan 14, 2014

Mar 19, 2012

13/423714

Gilles Clermont - Fombell PA, US
Patricia A. Hebda - Sarver PA, US
Yee Key Li - Pittsburgh PA, US
Qi Mi - Pittsburgh PA, US
David L. Steed - Pittsburgh PA, US
Joshua Thomas Sullivan - Butler PA, US
Katherine Verdolini Abbott - Cheswick PA, US
Yoram Vodovotz - Sewickley PA, US
Ivan Petrov Yotov - Pittsburgh PA, US
Gary An - Chicago IL, US

University of Pittsburgh—Of the Commonwealth System of Higher Education - Pittsburgh PA

G06F 19/00, G01N 33/50, G06G 7/58, A61K 38/00, A61K 38/18, A61P 17/02

702 19, 703 11, 514 14, 514 76, 514 94

Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.

8454957, Jun 4, 2013

Jun 17, 2011

13/134821

David L. Steed - Pittsburgh PA, US
William J. Golden - Boston MA, US

Stemnion, Inc. - Pittsburgh PA

A61K 35/12

4241301, 424 931, 514 141

The invention is directed to methods for treating coagulation disorders, in particular, hemophilia. Such methods utilize novel compositions including Amnion-derived Multipotent Progenitor cells (herein referred to as AMP cells) alone or in combination with other agents and/or treatment modalities.

8318197, Nov 27, 2012

Jan 17, 2012

13/374825

David L. Steed - Pittsburgh PA, US
Randall G. Rupp - Swanton VT, US
Howard C. Wessel - New Kensington PA, US

Stemnion, Inc. - Pittsburgh PA

A61F 13/00, A61F 15/00, A61L 15/00, A61L 15/16, C07K 14/00, A61K 35/14, A61K 38/18

424443, 424445, 424446, 424447, 530350, 530351, 530380, 514 81, 514 82, 514 89, 602 42, 602 43, 602 48, 602 50

The invention is directed to a novel wound healing device. In particular, the invention is directed to a novel wound healing device comprising a suture or knitted mesh that has adsorbed onto it novel cellular factor-containing compositions (referred to herein as CFC), including Amnion-derived Cellular Cytokine Solution (referred to herein as ACCS) or Physiologic Cytokine Solutions (herein referred to as PCS), as well as methods of making and uses thereof.

2013018, Jul 18, 2013

Mar 5, 2013

13/785371

David L. Steed - Pittsburgh PA, US
Randall G. Rupp - Swanton VT, US

STEMNION, INC. - Pittsburgh PA

A01N 1/02

435 12

The invention is directed to methods of modulating ischemic injury in tissues and organs. The invention is further directed to methods of increasing time to ischemic injury in tissues and organs. Such methods utilize compositions comprising cells capable of modulating inflammatory responses, referred to herein as Inflammatory Response Modulating Cells (IRMCs). The IRMCs any be used directly or cell membranes derived from them may be used in practicing the methods of the invention. In addition, the IRMCs and IRMC membranes may be used alone or in combination with each other and/or in combination with various suitable active agents.

8313764, Nov 20, 2012

Jun 20, 2011

13/134881

David L. Steed - Pittsburgh PA, US
Linda O. Palladino - Stormville NY, US

Stemnion, Inc. - Pittsburgh PA

A61F 13/00, A61F 15/00, A61L 15/00, A61L 15/16, C07K 14/00, A61K 35/14, A61K 38/18

424443, 424445, 424446, 424447, 530350, 530351, 530380, 514 81, 514 82, 514 89, 602 42, 602 43, 602 48, 602 50

The invention is directed to a wound healing device. Such wound healing device utilizes novel wound healing compositions embedded onto or into a natural plant-derived cloth-based matrix.