DAVID L PALMER
Barber in Gardenville, PA
License number
Pennsylvania SB065036
Category
Real Estate Commission
Type
Broker (Sole Proprietor)-Standard
Address
Address
Gardenville, PA 18901
Personal information
See more information about DAVID L PALMER at radaris.comName
Address
Phone
4951 Crowfoot Rd, Murrysville, PA 15668
472 Washington St, Saint Marys, PA 15857
469 Carmalot St, Irwin, PA 15642
Professional information
See more information about DAVID L PALMER at trustoria.com
Liquid Phase Process For The Preparation Of Gnrh Peptides
Liquid Phase Process For The Preparation Of Gnrh Peptides
US Patent:
6235876, May 22, 2001
Filed:
Jul 8, 1999
Appl. No.:
9/350231
Inventors:
David C. Palmer - Doylestown PA
Ahmed Abdel-Magid - Lansdale PA
Urs P. Eggmann - Flurligen, CH
Bruce Harris - Abington PA
Kirk L. Sorgi - Doylestown PA
Ahmed Abdel-Magid - Lansdale PA
Urs P. Eggmann - Flurligen, CH
Bruce Harris - Abington PA
Kirk L. Sorgi - Doylestown PA
Assignee:
Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ
International Classification:
C07K 704, C07K 706, C07K 508, C07K 510
US Classification:
530330
Abstract:
A liquid phase process for preparing GnRH peptide analogs of the formula:
G-AA. sub. 1 -(A)D-Phe-AA. sub. 3 -AA. sub. 4 -(R. sub. 2 -AA. sub. 5 -AA. sub. 6 -AA. sub. 7 -AA. sub. 8 -Pro-AA. sub. 10 -NH. sub. 2 Formula 1
which comprises:
(a) reacting a peptide of the formula:
T-(R. sub. 2)AA. sub. 5 -AA. sub. 6 -X
where T is (P. sub. 2) AA4 orP. sub. 2 and X is AA. sub. 7 -OH or is --OH, with a peptide of the formula:
X'-AA. sub. 8 -Pro-AA. sub. 10 -NH. sub. 2
or acid-addition salt form thereof, where X' is AA. sub. 7 when X is absent and X' is absent when X is AA. sub. 7 -OH;
in a liquid reaction medium in the presence of a peptide coupling reagent and a strong organic amine base to obtain a product of the formula:
T-(R. sub. 2)AA. sub. 5 -AA. sub. 6 -AA. sub. 7 -AA. sub. 8 -Pro-AA. sub. 10 -NH. sub. 2
(b) removing the P. sub. 2 protecting group at the N-terminus, and
(c) reacting the product of step (b) or an acid addition salt thereof, with a peptide of the formula:
G-AA. sub. 1 -(R. sub.
Process For The Preparation Of Piperazinyl And Diazepanyl Benzamide Derivatives
Process For The Preparation Of Piperazinyl And Diazepanyl Benzamide Derivatives
US Patent:
7893257, Feb 22, 2011
Filed:
Dec 10, 2007
Appl. No.:
11/953262
Inventors:
Anusuya Choudhury - Churchville PA, US
Jeffrey S. Grimm - Somerville NJ, US
Kirk L. Sorgi - Doylestown PA, US
David Palmer - Doylestown PA, US
Jing Liu - San Diego CA, US
Jeffrey S. Grimm - Somerville NJ, US
Kirk L. Sorgi - Doylestown PA, US
David Palmer - Doylestown PA, US
Jing Liu - San Diego CA, US
Assignee:
Janssen Pharmaceutica NV - Beerse
International Classification:
C07D 413/10
US Classification:
544121, 544106, 544111
Abstract:
The present invention is directed to a novel process for the preparation of piperazinyl and diazepanyl benzamide derivatives, useful for the treatment of disorders and conditions mediated by a histamine receptor, preferably the H3 receptor.
Novel Processes For The Preparation Of Cyclopropyl-Amide Derivatives
Novel Processes For The Preparation Of Cyclopropyl-Amide Derivatives
US Patent:
2012002, Feb 2, 2012
Filed:
Oct 11, 2011
Appl. No.:
13/270924
Inventors:
Neelakandha S. Mani - San Diego CA, US
David C. Palmer - Doylestown PA, US
Chennagiri R. Pandit - San Diego CA, US
Mayra B. Reyes - Somerset NJ, US
Tong Xiao - Edison NJ, US
Sergio Cesco-Cancian - Bethlehem PA, US
David C. Palmer - Doylestown PA, US
Chennagiri R. Pandit - San Diego CA, US
Mayra B. Reyes - Somerset NJ, US
Tong Xiao - Edison NJ, US
Sergio Cesco-Cancian - Bethlehem PA, US
International Classification:
C07D 413/10
US Classification:
544121
Abstract:
The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.
Process For The Preparation Of Substituted Pyrimidine Derivatives
Process For The Preparation Of Substituted Pyrimidine Derivatives
US Patent:
2013022, Aug 29, 2013
Filed:
Mar 15, 2013
Appl. No.:
13/844227
Inventors:
Janssen Pharmaceutica NV - , US
Hongfeng Chen - Somerville NJ, US
Jeffrey S. Grimm - Somerville NJ, US
Neelakandha S. Mani - San Diego CA, US
Christopher M. Mapes - La Jolla CA, US
David C. Palmer - Doylestown PA, US
Daniel J. Pippel - Del Mar CA, US
Kirk L. Sorgi - Doylestown PA, US
Tong Xiao - Edison NJ, US
Hongfeng Chen - Somerville NJ, US
Jeffrey S. Grimm - Somerville NJ, US
Neelakandha S. Mani - San Diego CA, US
Christopher M. Mapes - La Jolla CA, US
David C. Palmer - Doylestown PA, US
Daniel J. Pippel - Del Mar CA, US
Kirk L. Sorgi - Doylestown PA, US
Tong Xiao - Edison NJ, US
Assignee:
Janssen Pharmaceutica NV - New Brunswick NJ
International Classification:
C07D 401/12
US Classification:
544330
Abstract:
The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine Hreceptor modulators, and to intermediates in Hmodulator synthesis.
Process For The Preparation Of Substituted Pyrimidine Derivatives
Process For The Preparation Of Substituted Pyrimidine Derivatives
US Patent:
2014007, Mar 13, 2014
Filed:
Nov 13, 2013
Appl. No.:
14/079358
Inventors:
Hongfeng Chen - Somerville NJ, US
Jeffrey S. Grimm - Somerville NJ, US
Neelakandha S. Mani - San Diego CA, US
Christopher M. Mapes - La Jolla CA, US
David C. Palmer - Doylestown PA, US
Daniel J. Pippel - Del Mar CA, US
Kirk L. Sorgi - Doylestown PA, US
Tong Xiao - Edison NJ, US
Jeffrey S. Grimm - Somerville NJ, US
Neelakandha S. Mani - San Diego CA, US
Christopher M. Mapes - La Jolla CA, US
David C. Palmer - Doylestown PA, US
Daniel J. Pippel - Del Mar CA, US
Kirk L. Sorgi - Doylestown PA, US
Tong Xiao - Edison NJ, US
Assignee:
Janssen Pharmaceutica NV - New Brunswick NJ
International Classification:
C07D 211/26
US Classification:
546231
Abstract:
The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine Hreceptor modulators, and to intermediates in H4 modulator synthesis.
Process For The Preparation Of Benzoimidazol-2-Yl Pyrimidine Derivatgives
Process For The Preparation Of Benzoimidazol-2-Yl Pyrimidine Derivatgives
US Patent:
2012017, Jul 12, 2012
Filed:
Mar 22, 2012
Appl. No.:
13/427767
Inventors:
Sergio CESCO-CANCIAN - Bethlehem PA, US
Jeffrey S. GRIMM - Somerville NJ, US
Neelakandha S. MANI - San Diego CA, US
Christopher M. MAPES - La Mesa CA, US
David C. PALMER - Doylestown PA, US
Daniel J. PIPPEL - Del Mar CA, US
Tong XIAO - Edison NJ, US
Diego BROGGINI - Zurich, CH
Susanne LOCHNER - Singen, DE
Jeffrey S. GRIMM - Somerville NJ, US
Neelakandha S. MANI - San Diego CA, US
Christopher M. MAPES - La Mesa CA, US
David C. PALMER - Doylestown PA, US
Daniel J. PIPPEL - Del Mar CA, US
Tong XIAO - Edison NJ, US
Diego BROGGINI - Zurich, CH
Susanne LOCHNER - Singen, DE
International Classification:
C07D 401/14
US Classification:
544331
Abstract:
The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine Hreceptor modulators and processes for the preparation of such compounds.
Process For The Preparation Of Substituted Pyrimidine Derivatives
Process For The Preparation Of Substituted Pyrimidine Derivatives
US Patent:
8309720, Nov 13, 2012
Filed:
Jun 29, 2009
Appl. No.:
12/459229
Inventors:
Sergio Cesco-Cancian - Bethlehem PA, US
Hongfeng Chen - Wilmington DE, US
Jeffrey S. Grimm - Somerville NJ, US
Neelakandha S. Mani - San Diego CA, US
Christopher M. Mapes - La Mesa CA, US
David C. Palmer - Doylestown PA, US
Daniel J. Pippel - Del Mar CA, US
Kirk L. Sorgi - Doylestown PA, US
Tong Xiao - Edison NJ, US
Hongfeng Chen - Wilmington DE, US
Jeffrey S. Grimm - Somerville NJ, US
Neelakandha S. Mani - San Diego CA, US
Christopher M. Mapes - La Mesa CA, US
David C. Palmer - Doylestown PA, US
Daniel J. Pippel - Del Mar CA, US
Kirk L. Sorgi - Doylestown PA, US
Tong Xiao - Edison NJ, US
Assignee:
Janssen Pharmaceutica NV - Beerse
International Classification:
C07D 211/06, C07D 211/30
US Classification:
544330, 546246, 546248
Abstract:
The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine Hreceptor modulators, and to intermediates in H4 modulator synthesis.
Process For The Preparation Of Benzoimidazol-2-Yl Pyrimidine Derivatives
Process For The Preparation Of Benzoimidazol-2-Yl Pyrimidine Derivatives
US Patent:
2012018, Jul 19, 2012
Filed:
Mar 22, 2012
Appl. No.:
13/427798
Inventors:
Sergio Cesco-Cancian - Bethlehem PA, US
Jeffrey S. Grimm - Someville NJ, US
Neelakandha S. Mani - San Diego CA, US
Christopher M. Mapes - La Mesa CA, US
David C. Palmer - Doylestown PA, US
Daniel J. Pippel - Del Mar CA, US
Tong Xiao - Edison NJ, US
Diego Broggini - Zurich, CH
Susanne Lochner - Singen, DE
Jeffrey S. Grimm - Someville NJ, US
Neelakandha S. Mani - San Diego CA, US
Christopher M. Mapes - La Mesa CA, US
David C. Palmer - Doylestown PA, US
Daniel J. Pippel - Del Mar CA, US
Tong Xiao - Edison NJ, US
Diego Broggini - Zurich, CH
Susanne Lochner - Singen, DE
International Classification:
C07D 401/14
US Classification:
544331
Abstract:
The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine Hreceptor modulators and processes for the preparation of such compounds.
Processes For The Preparation Of Cyclopropyl-Amide Derivatives
Processes For The Preparation Of Cyclopropyl-Amide Derivatives
US Patent:
8063206, Nov 22, 2011
Filed:
Jul 20, 2010
Appl. No.:
12/840134
Inventors:
Neelakandha S. Mani - San Diego CA, US
David C. Palmer - Doylestown PA, US
Chennagiri R. Pandit - San Diego CA, US
Mayra B. Reyes - Somerset NJ, US
Tong Xiao - Edison NJ, US
Sergio Cesco-Cancian - Bethlehem PA, US
David C. Palmer - Doylestown PA, US
Chennagiri R. Pandit - San Diego CA, US
Mayra B. Reyes - Somerset NJ, US
Tong Xiao - Edison NJ, US
Sergio Cesco-Cancian - Bethlehem PA, US
Assignee:
Janssen Pharmaceutica NV - Beerse
International Classification:
C07D 413/10
US Classification:
544121
Abstract:
The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.
Processes For The Preparation Of Piperazinyl And Diazapanyl Benzamide Derivatives
Processes For The Preparation Of Piperazinyl And Diazapanyl Benzamide Derivatives
US Patent:
7728129, Jun 1, 2010
Filed:
Oct 26, 2006
Appl. No.:
11/553158
Inventors:
Neelakandha S. Mani - San Diego CA, US
David C. Palmer - Doylestown PA, US
Chennagiri R. Pandit - San Diego CA, US
Mayra B. Reyes - Somerset NJ, US
Tong Xiao - Edison NJ, US
Sergio Cesco-Cancian - Bethlehem PA, US
David C. Palmer - Doylestown PA, US
Chennagiri R. Pandit - San Diego CA, US
Mayra B. Reyes - Somerset NJ, US
Tong Xiao - Edison NJ, US
Sergio Cesco-Cancian - Bethlehem PA, US
Assignee:
Janssen Pharmaceutica NV - Beerse
International Classification:
C07D 413/10
US Classification:
544121
Abstract:
The present invention is directed to novel processes for the preparation of substituted piperazinyl and diazepanyl benzamides of formula (I), as defined in the specification, useful for the treatment of disorders and conditions mediated by the histamine receptor.