Inventors:
Jonathan F. Tait - Seattle WA
David S. Brown - Auburn WA
Assignee:
The University of Washington - Seattle WA
International Classification:
C07K 500
Abstract:
Modified annexins having an N-terminal chelation site comprising an amino acid extension are disclosed. The amino acid extension includes an amino acid sequence X. sub. 1 -Gly-X. sub. 2, where X. sub. 1 and X. sub. 2 are selected from Gly and Cys, where at least one of X. sub. 1 or X. sub. 2 is Cys. Radionuclides are readily chelated by the modified annexins to provide radiolabeled annexins useful in imaging vascular thrombi and apoptosis in vivo.