Inventors:
Peter Hotez - Bethesda MD, US
Alexander Loukas - Calros, AT
Mark Pearson - Buderim, AT
Jeffrey Bethony - Minas Gerais, BR
Bin Zhan - North Potomac MD, US
Gaddam Goud - Boyds MD, US
Maria Elena Bottazzi - Washington DC, US
David Diemert - Washington DC, US
Ami Shah Brown - Halethorpe MD, US
Peter Giacomantonio - Mansfield, AT
International Classification:
A61K 39/002
Abstract:
A multivalent anthelmintic vaccine targets both hookworm and schistosomiasis. The vaccine includes, at a minimum, a recombinant third-stage larval hookworm antigen, a recombinant adult stage hookworm antigen, and a recombinant schistosome antigen. Preferably, the hookworm antigens are antigens, although antigens from other hookworm species (e.g. ) may also be employed. The schistosome antigen is preferably a or a antigen although antigens from other schistosome species (e.g. ) may also be employed. In some cases full or partial sequences of schistosome antigens may be fused with full or partial sequences of hookworm {) to produce recombinant chimeric antigens.