DAVID JOHN TWEARDY
Medical Practice in Houston, TX
License number
Pennsylvania MD031144E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Houston, TX 77005
Pennsylvania
Pennsylvania
Personal information
See more information about DAVID JOHN TWEARDY at radaris.comName
Address
Phone
Houston, TX
722 Shady Ave, Pittsburgh, PA 15232
722 Shady Ave, Pittsburgh, PA 15232
3769 Nottingham St, Houston, TX 77005
Professional information
Structural Requirements For Stat3 Binding And Recruitment To Phosphotyrosine Ligands
US Patent:
2006014, Jul 6, 2006
Filed:
Dec 20, 2005
Appl. No.:
11/313104
Inventors:
David Tweardy - Houston TX, US
Assignee:
BAYLOR COLLEGE OF MEDICINE - Houston TX
International Classification:
A61K 38/10
US Classification:
514014000
Abstract:
Inhibitors of Stat3 are disclosed, including small molecules and peptide mimetic inhibitors. Specific Stat3 inhibitors of the invention are useful as beta-turn mimetics. Also disclosed are pharmaceutical compositions of the Stat3 inhibitors of the invention, and methods for using the compounds of the invention to inhibit growth of a cell or to inhibit protein-protein interactions modulated by SH2 domains. Methods of screening for Stat3 inhibitors are also provided.
Dr. David J Tweardy - MD (Doctor of Medicine)
Specialties:
Infectious Disease Medicine
Certifications:
Infectious Disease, 1984, Internal Medicine, 1983
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
1 Baylor Plz SUITE N, Houston 77030
6620 Main St, Houston 77030
Houston Office
1 Baylor Plz, Houston 77030
Ben Taub General Hospital
1504 Taub Loop, Houston 77030
The Methodist Hospital
6565 Fannin St, Houston 77030
1 Baylor Plz SUITE N, Houston 77030
6620 Main St, Houston 77030
Houston Office
1 Baylor Plz, Houston 77030
Ben Taub General Hospital
1504 Taub Loop, Houston 77030
The Methodist Hospital
6565 Fannin St, Houston 77030
6620 Main St, Houston 77030
Houston Office
1 Baylor Plz, Houston 77030
Ben Taub General Hospital
1504 Taub Loop, Houston 77030
The Methodist Hospital
6565 Fannin St, Houston 77030
1 Baylor Plz SUITE N, Houston 77030
6620 Main St, Houston 77030
Houston Office
1 Baylor Plz, Houston 77030
Ben Taub General Hospital
1504 Taub Loop, Houston 77030
The Methodist Hospital
6565 Fannin St, Houston 77030
Education:
Medical School
Harvard Medical School
Graduated: 1978
Case Western Res-U Clevelan
Harvard Medical School
Graduated: 1978
Case Western Res-U Clevelan
David Tweardy, Houston TX
Work:
One Baylor Plaza
1 Baylor Plz, Houston, TX 77030 Bimc -General Internal Medicine Baylor Clinic
6620 Main St, Houston, TX 77030
1 Baylor Plz, Houston, TX 77030 Bimc -General Internal Medicine Baylor Clinic
6620 Main St, Houston, TX 77030
Professor At Baylor College Of Medicin
Position:
Professor at Baylor College of Medicin
Location:
Houston, Texas Area
Industry:
Medical Practice
Work:
Baylor College of Medicin
-
Professor
Stat3 Inhibitors
US Patent:
2011031, Dec 22, 2011
Filed:
Jun 3, 2009
Appl. No.:
12/996073
Inventors:
David J. Tweardy - Houston TX, US
Wanzhi Huang - Houston TX, US
Moses M. Kasembeli - Houston TX, US
Wanzhi Huang - Houston TX, US
Moses M. Kasembeli - Houston TX, US
International Classification:
A61K 31/192, C12N 5/09, A61K 31/357, A61K 31/352, A61K 31/427, A61K 31/195, A61K 31/513, A61P 35/00, A61P 31/12, A61P 1/00, A61P 11/06, A61P 17/06, A61P 25/00, A61P 1/18, A61P 27/02, C12N 5/071
US Classification:
514274, 435375, 514452, 514457, 514369, 514562, 514569
Abstract:
Small molecule inhibitors of Stat3 and their derivatives are disclosed. Also described are methods to inhibit cell growth by use of Stat3 inhibitors, and the use of Stat3 inhibitors for the prevention and/or treatment of cancer. Further, inhibitors of Stat3 that also do not inhibit Stat1 are described as well as their derivatives. Methods of screening additional compounds for Stat3 inhibition activity and/or non-inhibition of Stat1 activity are also described herein.
Stat3 Inhibitors
US Patent:
2010004, Feb 18, 2010
Filed:
Jun 3, 2009
Appl. No.:
12/477583
Inventors:
David J. Tweardy - Houston TX, US
Xuejun Xu - Missouri City TX, US
Moses M. Kasembeli - Houston TX, US
Xuejun Xu - Missouri City TX, US
Moses M. Kasembeli - Houston TX, US
International Classification:
A61K 31/505, A61K 31/357, A61K 31/427, A61K 31/195, A61P 35/00, A61P 11/00, A61P 1/00, A61K 31/366
US Classification:
514274, 514452, 514369, 514562, 514456
Abstract:
Small molecule inhibitors of Stat3 and their derivatives are disclosed. Also described are methods to inhibit cell growth by use of Stat3 inhibitors, and the use of Stat3 inhibitors for the prevention and/or treatment of cancer. Further, inhibitors of Stat3 that also do not inhibit Stat1 are described as well as their derivatives. Methods of screening additional compounds for Stat3 inhibition activity and/or non-inhibition of Stat1 activity are also described herein.