DAVID J FINK, MD
Neurology in Ann Arbor, MI
License number
Michigan 4301044681
Category
Neurology
Type
Neurology
Address
Address
1500 Floor Taubman Ctr, Ann Arbor, MI 48109
Phone
(734) 936-9010
(734) 936-2047
(734) 936-2047
Personal information
See more information about DAVID J FINK at radaris.comName
Address
Phone
4815 N Anna Ln, Sanford, MI 48657
5503 Meadowcrest Dr, Flint, MI 48532
3630 Pine Hill Ct, West Bloomfield, MI 48323
3580 Pheasant Run Cir APT 5, Ann Arbor, MI 48108
3725 Sunset Blvd, Orchard Lake, MI 48324
Professional information
David J Fink, Ann Arbor MI
Specialties:
Neurologist
Address:
1500 E Medical Center Dr, Ann Arbor, MI 48109
Education:
Harvard Medical School - Doctor of Medicine
UCSF Medical Center - Residency - Neurology
Massachusetts General Hospital - Residency - Internal Medicine
UCSF Medical Center - Residency - Neurology
Massachusetts General Hospital - Residency - Internal Medicine
Board certifications:
American Board of Internal Medicine Certification in Internal Medicine, American Board of Psychiatry and Neurology Certification in Neurology (Psychiatry and Neurology)
Hsv-1 Vector Containing A Lat Promoter
US Patent:
5849572, Dec 15, 1998
Filed:
Mar 28, 1995
Appl. No.:
8/411920
Inventors:
Joseph C. Glorioso - Cheswick PA
David J. Fink - Ann Arbor MI
David J. Fink - Ann Arbor MI
Assignee:
Regents of the University of Michigan - Ann Arbor MI
International Classification:
C12N 1500, C12N 700, C07H 2104
US Classification:
4353201
Abstract:
A gene transfer vector for transferring genetic material to a host tissue and expressing a gene product therefrom includes a virus capable of establishing extra chromosomal viral latency in the host tissue. The strain includes at least one foreign gene recombined into the virus which is foreign to the viral genome and a promoter for initiating and driving transcription of the foreign gene during latency of the virus in the host tissue.
Dr. David J Fink, Ann Arbor MI - MD (Doctor of Medicine)
Specialties:
Internal Medicine, Neuropsychiatry (Neurology)
Address:
UM Adult Neurology Outptnt Svcs
1500 E Medical Center Dr SUITE 1324, Ann Arbor 48109
(734) 936-9020 (Phone)
1500 E Medical Center Dr SUITE 1324, Ann Arbor 48109
(734) 936-9020 (Phone)
Certifications:
Internal Medicine, 1977, Neurology, 1984
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
Harvard Medical School
Graduated: 1974
Massachusetts General Hospital
University Of California-San Francisco
Harvard Medical School
Graduated: 1974
Massachusetts General Hospital
University Of California-San Francisco
David Fink, Ann Arbor MI
Specialties:
Internal Medicine, Neurology
Work:
Ann Arbor Veterans Affairs Medical Center
2215 Fuller Rd, Ann Arbor, MI 48105 University-Pittsburg Physician
3601 5Th Ave, Pittsburgh, PA 15213
2215 Fuller Rd, Ann Arbor, MI 48105 University-Pittsburg Physician
3601 5Th Ave, Pittsburgh, PA 15213
Education:
Harvard University(1974)
Method Of Amidated Peptide Biosynthesis And Delivery In Vivo: Endomorphin-2 For Pain Therapy
US Patent:
7825231, Nov 2, 2010
Filed:
Jun 1, 2006
Appl. No.:
11/445837
Inventors:
Darren P. Wolfe - Verona PA, US
Joseph C. Glorioso - Fox Chapel PA, US
David J. Fink - Ann Arbor MI, US
Joseph C. Glorioso - Fox Chapel PA, US
David J. Fink - Ann Arbor MI, US
Assignee:
Regents of the University of Michigan - Ann Arbor MI
International Classification:
C07H 21/04, A61K 31/711, C12N 15/12, C12N 15/62
US Classification:
536 234, 514 44 R, 4353201
Abstract:
The invention provides an expression cassette comprising a DNA sequence encoding amino acids 1-99 of human preproenkephalin, a DNA sequence encoding a precursor of a carboxy-amidated peptide flanked by dibasic cleavage sites and optionally a DNA sequence encoding a marker protein (such as Enhanced Green Fluorescent Protein (GFP)) all in operable linkage and under control of a promoter. Where the encoded precursor of a carboxy-amidated peptide is an agonist for an opioid receptor, the invention further provides a method of treating neuropathic pain by administering the gene transfer vector comprising such an expression cassette to a patient. The invention also provides a method for detecting a peptide having a desired effect comprising introducing a library of DNA sequences encoding one or more precursors of carboxy-amidated peptides into host cells; expressing the carboxy-amidated peptides encoded in the library to provide expression products; and screening from the polypeptide expression products for the desired effect.
Peripherally Delivered Glutamic Acid Decarboxylase Gene Therapy For Spinal Cord Injury Pain
US Patent:
2007020, Sep 6, 2007
Filed:
Oct 28, 2005
Appl. No.:
11/261389
Inventors:
Joseph Glorioso - Blawnox PA, US
David Fink - Ann Arbor MI, US
Darren Wolfe - Verona PA, US
David Krisky - Sewickley PA, US
David Fink - Ann Arbor MI, US
Darren Wolfe - Verona PA, US
David Krisky - Sewickley PA, US
Assignee:
University of Pittsburgh of the Commonwealth System of Higher Education - Pittsburgh PA
Department of Veterans Affairs (024) - Washington DC
Department of Veterans Affairs (024) - Washington DC
International Classification:
A61K 48/00, C12N 15/86
US Classification:
424093200, 514044000, 435456000, 435325000
Abstract:
The invention provides a vector, preferably a herpes simplex virus (HSV) vector, comprising a polynucleotide sequence encoding a glutamic acid decarboxylase (GAD) protein. The invention also provides a stock of such vectors and a pharmaceutical composition comprising such vectors. The invention further provides a method of treating pain, such as spinal cord injury pain, in a mammal comprising administering to a mammal a vector comprising a nucleotide sequence encoding a glutamic acid decarboxylase (GAD) protein in an amount effective to treat spinal cord injury pain.
Peptide Biosynthesis And Pain Therapy
US Patent:
8003622, Aug 23, 2011
Filed:
Sep 29, 2010
Appl. No.:
12/893255
Inventors:
Darren P. Wolfe - Pittsburgh PA, US
Joseph C. Glorioso - Pittsburgh PA, US
David J. Fink - Ann Arbor MI, US
Joseph C. Glorioso - Pittsburgh PA, US
David J. Fink - Ann Arbor MI, US
Assignee:
Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 48/00, C12N 15/00
US Classification:
514 44R, 4353201
Abstract:
The invention provides an expression cassette comprising a DNA sequence encoding amino acids 1-99 of human preproenkephalin, a DNA sequence encoding a precursor of a carboxy-amidated peptide flanked by dibasic cleavage sites and optionally a DNA sequence encoding a marker protein (such as Enhanced Green Fluorescent Protein (GFP)) all in operable linkage and under control of a promoter. Where the encoded precursor of a carboxy-amidated peptide is an agonist for an opioid receptor, the invention further provides a method of treating neuropathic pain by administering the gene transfer vector comprising such an expression cassette to a patient. The invention also provides a method for detecting a peptide having a desired effect comprising introducing a library of DNA sequences encoding one or more precursors of carboxy-amidated peptides into host cells; expressing the carboxy-amidated peptides encoded in the library to provide expression products; and screening from the polypeptide expression products for the desired effect.
Peptide Biosynthesis And Pain Therapy
US Patent:
2011011, May 12, 2011
Filed:
Sep 29, 2010
Appl. No.:
12/893352
Inventors:
DARREN P. WOLFE - PITTSBURGH PA, US
JOSEPH C. GLORIOSO - PITTSBURGH PA, US
DAVID J. FINK - ANN ARBOR MI, US
JOSEPH C. GLORIOSO - PITTSBURGH PA, US
DAVID J. FINK - ANN ARBOR MI, US
Assignee:
REGENTS OF THE UNIVERSITY OF MICHIGAN - ANN ARBOR MI
International Classification:
A61K 31/7088, C07H 21/00, C40B 40/08, C12N 15/63, A61P 29/00, A61P 25/04
US Classification:
514 44 R, 536 235, 506 17, 4353201
Abstract:
The invention provides an expression cassette comprising a DNA sequence encoding amino acids 1-99 of human preproenkephalin, a DNA sequence encoding a precursor of a carboxy-amidated peptide flanked by dibasic cleavage sites and optionally a DNA sequence encoding a marker protein (such as Enhanced Green Fluorescent Protein (GNP)) all in operable linkage and under control of a promoter. Where the encoded precursor of a carboxy-amidated peptide is an agonist for an opioid receptor, the invention further provides a method of treating neuropathic pain by administering the gene transfer vector comprising such an expression cassette to a patient. The invention also provides a method for detecting a peptide having a desired effect comprising introducing a library of DNA sequences encoding one or more precursors of carboxy-amidated peptides into host cells; expressing the carboxy-amidated peptides encoded in the library to provide expression products; and screening from the polypeptide expression products for the desired effect.