MR. DAVID HENRY LIU, PA-C
Medical Practice at Ascension Dr, Los Altos, CA
License number
California 51475
Category
Nursing
Type
Medical
Address
Address
26550 Ascension Dr, Los Altos, CA 94022
Phone
(650) 208-1576
Professional information
Devices And Methods For Thermally Isolating Chambers Of An Assay Card
US Patent:
2009008, Mar 26, 2009
Filed:
Sep 21, 2007
Appl. No.:
11/859180
Inventors:
Joon Mo Yang - Redwood City CA, US
David M. Liu - Los Altos CA, US
Yuh-Min Chiang - Foster City CA, US
Carol Schrembri - San Mateo CA, US
Aldrich N.K. Lau - Palo Alto CA, US
Umberto Ulmanella - Foster City CA, US
Nigel P. Beard - Redwood City CA, US
Maryam Shariati - Sunnyvale CA, US
James C. Nurse - Pleasanton CA, US
Douwe D. Haga - Redwood City CA, US
Ian A. Harding - San Mateo CA, US
Julio P. Focaracci - San Mateo CA, US
David M. Liu - Los Altos CA, US
Yuh-Min Chiang - Foster City CA, US
Carol Schrembri - San Mateo CA, US
Aldrich N.K. Lau - Palo Alto CA, US
Umberto Ulmanella - Foster City CA, US
Nigel P. Beard - Redwood City CA, US
Maryam Shariati - Sunnyvale CA, US
James C. Nurse - Pleasanton CA, US
Douwe D. Haga - Redwood City CA, US
Ian A. Harding - San Mateo CA, US
Julio P. Focaracci - San Mateo CA, US
Assignee:
Applera Corporation - Foster City CA
International Classification:
C12M 1/34, B29C 59/02, B29C 59/16
US Classification:
4352884, 264293, 264442, 264101
Abstract:
An assay card and devices and methods for isolating chambers on the assay card are described. The assay card comprises a substrate formed of one or more materials, e.g., plastic, having a softening temperature, the substrate defining channels communicating with respective reaction chambers. The assay card may be heated in a region of the channels to at least the softening temperature. The softened plastic may be deformed, e.g., with a tool which may or may not also provide the heat for softening the substrate. In this manner, the plastic of the substrate may be caused to at least partially obstruct the channels, thereby isolating the reaction chambers. The invention also relates to a method of manufacturing a tool device that includes pins for heating and deforming an assay card.
Devices And Methods For Controlling Bubble Formation In Microfluidic Devices
US Patent:
2007028, Dec 6, 2007
Filed:
Jun 2, 2006
Appl. No.:
11/422057
Inventors:
Umberto Ulmanella - Foster City CA, US
Eric S. Nordman - Palo Alto CA, US
Maengseok Song - Burlingame CA, US
Joon Mo Yang - Redwood City CA, US
Julie C. Lee - Sunnyvale CA, US
Nigel P. Beard - Redwood City CA, US
Min Yue - Belmont CA, US
Carol Schembri - San Mateo CA, US
David Liu - Los Altos CA, US
Eric S. Nordman - Palo Alto CA, US
Maengseok Song - Burlingame CA, US
Joon Mo Yang - Redwood City CA, US
Julie C. Lee - Sunnyvale CA, US
Nigel P. Beard - Redwood City CA, US
Min Yue - Belmont CA, US
Carol Schembri - San Mateo CA, US
David Liu - Los Altos CA, US
Assignee:
APPLERA CORPORATION - Foster City CA
International Classification:
B01L 3/02
US Classification:
422100
Abstract:
A microfluidic device may include a sample distribution network including a plurality of sample chambers configured to be loaded with biological sample for biological testing of the biological sample while in the sample chambers, the biological sample having a meniscus that moves within the sample chambers during loading. The sample distribution network may further include a plurality of inlet channels, each inlet channel being in flow communication with and configured to flow biological sample to a respective sample chamber, and a plurality of outlet channels, each outlet channel being in flow communication and configured to flow biological sample from a respective sample chamber. At least some of the sample chambers may include a physical modification configured to control the movement of the meniscus so as to control bubble formation within the at least some sample chambers. At least some of the sample chambers may include a dried reagent positioned within the at least some sample chambers proximate the inlet channels in flow communication with the at least some sample chambers.
Drug Dispensing Event Detector
US Patent:
4939705, Jul 3, 1990
Filed:
Nov 23, 1988
Appl. No.:
7/275294
Inventors:
Richard G. Hamilton - Fremont CA
David M. Liu - Los Altos CA
David M. Liu - Los Altos CA
Assignee:
Aprex Corporation - Fremont CA
International Classification:
G04B 4700, G07F 1100
US Classification:
368 10
Abstract:
A device for detecting the dispensing of drugs from a container in a way which eliminates false detection events due to mishandling of the container is disclosed. The device includes a container which may be opened and closed. It also contains a means for detecting the opening and separately detecting the closing of the container as well as means for measuring the time between these events and comparing this elapsed time to a predetermined standard indicative of drug dispensing event. The times of proper drug dispensing events are stored in the device for use by the health care professional following the patient's drug dosing compliance. Other opening and closing intervals which fall outside this time range give rise to an alternative response. They may be recorded with a notation of their probable error or they may be disregarded. In other aspects, the invention provides a preferred physical configuration for the electronic components of the device and a preferred means for accessing the data stored in the device.
Systems And Methods For Multiple Analyte Detection
US Patent:
2007001, Jan 18, 2007
Filed:
Apr 26, 2006
Appl. No.:
11/380327
Inventors:
Min Yue - Belmont CA, US
David Liu - Los Altos CA, US
Yuh-Min Chiang - Foster City CA, US
Joon Mo Yang - Redwood City CA, US
Dennis Lehto - Santa Clara CA, US
Charles Vann - El Granada CA, US
Nigel Beard - Redwood City CA, US
Ian Harding - San Mateo CA, US
John Van Camp - San Ramon CA, US
Alexander Dromaretsky - Davis CA, US
Sergey Ermakov - Hayward CA, US
Mark Oldham - Los Gatos CA, US
Joy Roy - San Jose CA, US
Maryam Shariati - Sunnyvale CA, US
Umberto Ulmanella - Foster City CA, US
David Liu - Los Altos CA, US
Yuh-Min Chiang - Foster City CA, US
Joon Mo Yang - Redwood City CA, US
Dennis Lehto - Santa Clara CA, US
Charles Vann - El Granada CA, US
Nigel Beard - Redwood City CA, US
Ian Harding - San Mateo CA, US
John Van Camp - San Ramon CA, US
Alexander Dromaretsky - Davis CA, US
Sergey Ermakov - Hayward CA, US
Mark Oldham - Los Gatos CA, US
Joy Roy - San Jose CA, US
Maryam Shariati - Sunnyvale CA, US
Umberto Ulmanella - Foster City CA, US
Assignee:
Applera Corporation - Foster City CA
International Classification:
B01L 3/00
US Classification:
422100000
Abstract:
Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
System Comprising Dual-Sided Thermal Cycler And Emulsion Pcr In Pouch
US Patent:
2010026, Oct 14, 2010
Filed:
Apr 8, 2010
Appl. No.:
12/756783
Inventors:
David LIU - Los Altos CA, US
Joon Mo YANG - Redwood City CA, US
Maryam SHARIATI - Sunnyvale CA, US
Sam WOO - Redwood City CA, US
David M. COX - Foster City CA, US
Dennis A. LEHTO - Santa Clara CA, US
Joon Mo YANG - Redwood City CA, US
Maryam SHARIATI - Sunnyvale CA, US
Sam WOO - Redwood City CA, US
David M. COX - Foster City CA, US
Dennis A. LEHTO - Santa Clara CA, US
Assignee:
APPLIED BIOSYSTEMS, LLC - Carlsbad CA
International Classification:
C12P 19/34, C12M 1/00
US Classification:
435 912, 4352891
Abstract:
A system and method are provided for large volume sample amplification adaptable for use with conventional PCR-based reactions as well as emulsion-based PCR reactions. A sample is retained in a pouch or flexible bag which permits bulk PCR amplification with efficient heat-transfer properties. For applications involving emulsion-based PCR amplification, the system and method provide improved uniformity in emulsion amplification and can be used to amplify large or small volume emulsions rapidly and reproducibly.
Multi-Material Microplate And Method
US Patent:
2009000, Jan 1, 2009
Filed:
Jun 25, 2008
Appl. No.:
12/215145
Inventors:
David M. Liu - Los Altos CA, US
Gary Lim - San Francisco CA, US
Victor H. Yee - Castro Valley CA, US
Gary Lim - San Francisco CA, US
Victor H. Yee - Castro Valley CA, US
Assignee:
Applera Corporation - Foster City CA
International Classification:
B01L 3/00, B29C 45/02
US Classification:
422102, 264255
Abstract:
A microplate assembly for performing an analytical method on an assay, comprising a microplate base structure having a plurality of apertures formed therethrough, and a plurality of well inserts coupled to the microplate base structure adjacent the apertures. Each of the plurality of well inserts has an open top portion and is adapted to receive an assay. The microplate base structure and the plurality of well inserts can comprise different materials. Methods of manufacturing the microplate assembly are also provided.
Methods And Assemblies For Collecting Liquid By Centrifugation
US Patent:
8602958, Dec 10, 2013
Filed:
Nov 26, 2008
Appl. No.:
12/324655
Inventors:
Patrick D. Kinney - Hayward CA, US
Michele E. Wisniewski - San Diego CA, US
Jon A. Hoshizaki - Cupertino CA, US
David M. Liu - Los Altos CA, US
Joon Mo Yang - Redwood City CA, US
Michele E. Wisniewski - San Diego CA, US
Jon A. Hoshizaki - Cupertino CA, US
David M. Liu - Los Altos CA, US
Joon Mo Yang - Redwood City CA, US
Assignee:
Life Technologies Corporation - Carlsbad CA
International Classification:
B01D 21/26
US Classification:
494 37, 422548, 422553
Abstract:
Assemblies for and methods of coupling a microtiter plate and receptacle for centrifugation of liquid from the microtiter plate to the receptacle are provided. In some embodiments, a coupling frame can be used. In other embodiments, the microtiter plate couples directly to the receptacle. In some embodiments, relative motion between the receptacle and the microtiter plate is limited in the x-y plane. In some embodiments, relative motion between the receptacle and the microtiter plate is limited in the x-z plane. In some embodiments, relative motion between the receptacle and the microtiter plate is limited in the y-z plane.
Cover For Quality Control Testing Of An Iontophoretic Sampling System
US Patent:
D438807, Mar 13, 2001
Filed:
Mar 20, 2000
Appl. No.:
D/120567
Inventors:
David M. Liu - Los Altos CA
Assignee:
Cygnus, Inc. - Redwood City CA
International Classification:
1004
US Classification:
D10 81
Systems And Methods For Multiple Analyte Detection
US Patent:
8597590, Dec 3, 2013
Filed:
May 27, 2010
Appl. No.:
12/789363
Inventors:
Min Yue - Belmont CA, US
David M. Liu - Los Altos CA, US
Joy Roy - San Jose CA, US
Yuh-Min Chiang - Sunnyvale CA, US
Joon Mo Yang - Redwood City CA, US
Dennis Lehto - Santa Clara CA, US
Charles S. Vann - Marietta GA, US
Nigel P. Beard - Redwood City CA, US
Ian A. Harding - San Mateo CA, US
John R. Van Camp - San Ramon CA, US
Alexander Dromaretsky - Davis CA, US
Sergey V. Ermakov - Hayward CA, US
Mark F. Oldham - Foster City CA, US
Maryam Shariati - Sunnyvale CA, US
Umberto Ulmanella - Foster City CA, US
David M. Liu - Los Altos CA, US
Joy Roy - San Jose CA, US
Yuh-Min Chiang - Sunnyvale CA, US
Joon Mo Yang - Redwood City CA, US
Dennis Lehto - Santa Clara CA, US
Charles S. Vann - Marietta GA, US
Nigel P. Beard - Redwood City CA, US
Ian A. Harding - San Mateo CA, US
John R. Van Camp - San Ramon CA, US
Alexander Dromaretsky - Davis CA, US
Sergey V. Ermakov - Hayward CA, US
Mark F. Oldham - Foster City CA, US
Maryam Shariati - Sunnyvale CA, US
Umberto Ulmanella - Foster City CA, US
Assignee:
Applied Biosystems, LLC - Carlsbad CA
International Classification:
G01N 21/75
US Classification:
422402, 4352884, 4352883, 4352975, 4353031, 436180, 436518
Abstract:
Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
Flow Cells And Methods Of Filling And Using Same
US Patent:
2011005, Mar 3, 2011
Filed:
Aug 31, 2010
Appl. No.:
12/872997
Inventors:
Kirk HIRANO - Foster City CA, US
Mark ANDERSEN - Carlsbad CA, US
Jian GONG - San Marcos CA, US
Sam WOO - Redwood City CA, US
David COX - Foster City CA, US
Joon Mo YANG - Redwood City CA, US
Min YUE - Belmont CA, US
Maryam SHARIATI - Sunnyvale CA, US
John BRIDGHAM - Hillsborough CA, US
David LIU - Los Altos CA, US
Mark ANDERSEN - Carlsbad CA, US
Jian GONG - San Marcos CA, US
Sam WOO - Redwood City CA, US
David COX - Foster City CA, US
Joon Mo YANG - Redwood City CA, US
Min YUE - Belmont CA, US
Maryam SHARIATI - Sunnyvale CA, US
John BRIDGHAM - Hillsborough CA, US
David LIU - Los Altos CA, US
Assignee:
LIFE TECHNOLOGIES CORPORATION - Carlsbad CA
International Classification:
G01N 33/00, B32B 37/12
US Classification:
422 681, 1562757
Abstract:
Various flowcell configurations and systems are provided as are methods of making and using same. The flowcells, systems, and methods of use can be useful in carrying out sequencing reactions and next generation sequencing methods.