DAVID HARRY GODDARD
Medical Practice in Great Neck, NY

5728560, Mar 17, 1998

Jun 14, 1996

8/663685

Robert G. L. Shorr - Edison NJ
Mike A. Clark - Big Pine Key FL
David H. Goddard - Great Neck NY

Enzon, Inc. - Piscataway NJ

A61K 3843, C12N 900, C12N 978

435183

The present invention is directed to methods of treating CD4+ T cell lymphopenia in HIV-infected patients. The methods include administering an effective mount of adenosine deaminase or related enzymatic material to a patient in need thereof. In preferred aspects of the invention, the method is employed in conjunction with HIV-infected patients having CD4+ T cell levels of less than about 200/. mu. l. Effective amounts of the enzyme range from about 5 to about 50 IU/kg/week. In one particularly preferred aspect of the invention, the adenosine deaminase is conjugated to one or more strands of polyethylene glycol to prolonged activity in vivo.

5602094, Feb 11, 1997

Mar 29, 1994

8/219506

David Goddard - Great Neck NY

A61K 3809

514 12

Malignant gliomas are treated by modifying the eicosanoid biosynthetic pathway with reduction of the inhibitory effect of prostanoids on the cytotoxic activity of NK and LAK cells. Synthetic peptides, corresponding to shared sequences with phospholipase activating protein (PLAP), having the capacity to activate phospholipase A. sub. 2 (PLA. sub. 2), when administered in a delayed release delivery system, such as with agarose beads induce release of PGE. sub. 2, with significant tumor necrosis. A tumor model comprising an air pouch in the dorsum of rats is utilized for effective evaluation of the treatment, with tumor growth, treatment and evaluation of tumors grown therein.