DR. DAVID H WALKER, M.D.
Medical Practice at University Blvd, Galveston, TX
License number
Texas H5380
Category
Medical Practice
Type
Clinical Pathology/Laboratory Medicine
Address
Address
301 University Blvd, Galveston, TX 77555
Phone
(409) 772-3989
(409) 772-1850 (Fax)
(409) 772-1850 (Fax)
Personal information
See more information about DAVID H WALKER at radaris.comName
Address
Phone
4809 Widener Strip, Midland, TX 79707
4821 Timberview Dr Apt H, Sherman, TX 75090
4637 Marguerite Ln, Fort Worth, TX 76123
4712 Lariat Trl, Fort Worth, TX 76180
5003 French Wood Dr, Arlington, TX 76016
Organization information
See more information about DAVID H WALKER at bizstanding.comUtmb - David H Walker MD
301 University Blvd #1116, Galveston, TX 77555
Categories:
Pathology Physicians & Surgeons
Phone:
(409) 772-2856 (Phone)
Professional information
See more information about DAVID H WALKER at trustoria.com
David P. Walker, Galveston TX - Lawyer
David P. Walker, Galveston TX - Lawyer
Office:
1919 Sealy St, Galveston, TX
Specialties:
Conspiracy, Fraud, Federal Cases, Drunken Driving Defense - DWI/DUI, Computer Crimes, Narcotic Sales, Drug Possession, Assaults, Juvenile Charges, Theft, Sex Crimes, Murder, Intoxication Manslaughter, Expunctions and Orders of Non-Disclosure
ISLN:
903003566
Admitted:
1974
University:
Texas A & M University, B.S.
Law School:
South Texas College of Law, J.D.
28-Kda Immunoreactive Protein Gene Of Ehrlichia Canis And Uses Thereof
28-Kda Immunoreactive Protein Gene Of Ehrlichia Canis And Uses Thereof
US Patent:
6458942, Oct 1, 2002
Filed:
Nov 30, 1998
Appl. No.:
09/201458
Inventors:
David H. Walker - Galveston TX
Jere W. McBride - Galveston TX
Jere W. McBride - Galveston TX
Assignee:
Research Development Foundation
International Classification:
C12N 1511
US Classification:
536 235, 536 231, 435 691, 4352523, 435 698, 4353001
Abstract:
The present invention is directed to the cloning, sequencing and expression of a conserved immunoreactive 28-kDa protein gene (P28) from a polymorphic multiple gene family of P28 has an 834-bp open reading frame encoding a protein of 278 amino acids with four variable regions, and shares similar surface-exposed regions, antigenicity and T-cell motifs with P28. Also disclosed is that recombinant P28 protein reacts with convalescent phase antiserum from an -infected dog.
Homologous 28-Kilodalton Immunodominant Protein Genes Of Ehrlichia Canis And Uses Thereof
Homologous 28-Kilodalton Immunodominant Protein Genes Of Ehrlichia Canis And Uses Thereof
US Patent:
6403780, Jun 11, 2002
Filed:
Mar 3, 1999
Appl. No.:
09/261358
Inventors:
David H. Walker - Galveston TX
Jere W. McBride - Galveston TX
Jere W. McBride - Galveston TX
Assignee:
Research Development Foundation - Carson City NV
International Classification:
C12N 1500
US Classification:
536 231, 536 235, 536 237, 536 242, 435325, 4352523, 43525411, 4352551, 4353201, 435326, 530350
Abstract:
The present invention is directed to the cloning, sequencing and expression of homologous immunoreactive 28-kDa protein genes, ECa28-1 and ECa28SA3, from a polymorphic multiple gene family of A complete sequence of another 28-kDa protein gene, ECaSA2, is also provided. Further disclosed is a multigene locus encoding all five homologous 28-kDa protein genes of Recombinant 28-kDa proteins react with convalescent phase antiserum from an -infected dog.
Ehrlichia Chaffeensis 28 Kda Outer Membrane Protein Multigene Family
Ehrlichia Chaffeensis 28 Kda Outer Membrane Protein Multigene Family
US Patent:
2002006, May 30, 2002
Filed:
May 1, 2001
Appl. No.:
09/846808
Inventors:
David Walker - Galveston TX, US
International Classification:
A61K039/02, C12N009/02, C07H021/04, C12N015/74, C12P021/02, C12N001/21
US Classification:
424/190100, 424/234100, 536/023200, 435/320100, 435/252300, 435/189000, 435/069100
Abstract:
The 28-kDa outer membrane proteins (P28) of are encoded by a multigene family consisting of 21 members located in a 23-kb DNA fragment in the genome of . Fifteen of these proteins are claimed herein as novel sequences. The amino acid sequence identity of the various P28 proteins was 20-83%. Six of 10 tested p28 genes were actively transcribed in cell culture grown . RT-PCR also indicated that each of the p28 genes was monocistronic. These results suggest that the p28 genes are active genes and encode polymorphic forms of the P28 proteins. The P28s were also divergent among different isolates of . The large repertoire of the p28 genes in a single ehrlichial organism and antigenic diversity of the P28 among the isolates of suggest that the P28s may be involved in immune avoidance.
Ehrlichia Chaffeensis 28 Kda Outer Membrane Protein Multigene Family
Ehrlichia Chaffeensis 28 Kda Outer Membrane Protein Multigene Family
US Patent:
2003015, Aug 21, 2003
Filed:
Oct 31, 2002
Appl. No.:
10/285042
Inventors:
David Walker - Galveston TX, US
Assignee:
Research Development Foundation
International Classification:
A61K039/02, C07K001/00, C07K014/00, C07K017/00
US Classification:
530/350000
Abstract:
The 28-kDa outer membrane proteins (P28) of are encoded by a multigene family consisting of 21 members located in a 23-kb DNA fragment in the genome of Fifteen of these proteins are claimed herein as novel sequences. The amino acid sequence identity of the various P28 proteins was 20-83%. Six of 10 tested p28 genes were actively transcribed in cell culture grown RT-PCR also indicated that each of the p28 genes was monocistronic. These results suggest that the p28 genes are active genes and encode polymorphic forms of the P28 proteins. The P28were also divergent among different isolates of The large repertoire of the p28 genes in a single ehrlichial organism and antigenic diversity of the P28 among the isolates of suggest that the P28may be involved in immune avoidance.
Method Of Diagnosing And Treating Ehrlichia
Method Of Diagnosing And Treating Ehrlichia
US Patent:
2011011, May 19, 2011
Filed:
Nov 10, 2010
Appl. No.:
12/927220
Inventors:
David H. Walker - Galveston TX, US
Sunil Thomas - Dickinson TX, US
Sunil Thomas - Dickinson TX, US
International Classification:
A61K 39/02, C07K 14/00, A61K 38/16, C07K 16/00, A61P 31/04, A61P 37/04, G01N 33/53
US Classification:
4242341, 530326, 514 214, 5303879, 435 71, 435 79
Abstract:
The present invention provides an isolated and purified heat shock protein 60 (Hsp60) peptide having the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a vaccine against comprising a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to an antibody directed against a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a method of determining whether a subject is infected with , comprising the steps of: contacting a sample from a subject with the antibody described herein; and detecting a resulting antibody reaction, wherein a positive reaction indicates the subject is infected with
Homologous 28-Kilodalton Immunodominant Protein Genes Of And Uses Thereof
Homologous 28-Kilodalton Immunodominant Protein Genes Of And Uses Thereof
US Patent:
7344719, Mar 18, 2008
Filed:
Dec 9, 2003
Appl. No.:
10/731554
Inventors:
David H. Walker - Galveston TX, US
Jere W. McBride - Galveston TX, US
Jere W. McBride - Galveston TX, US
Assignee:
Research Development Foundation - Carson City NV
International Classification:
A61K 39/00, A61K 39/02, C07H 21/04, C12P 21/02, C12N 15/09
US Classification:
4241841, 4242341, 435 693, 435 697, 435 912, 435326, 435340, 536 235, 536 237, 514 2, 514 12
Abstract:
The present invention is directed to the cloning, sequencing and expression of homologous immunoreactive 28-kDa protein genes, p28-1, -2, -3, -5, -6, -7, -9, from a polymorphic multiple gene family of. Further disclosed is a multigene locus encoding all nine homologous 28-kDa protein genes of. Recombinant 28-kDa proteins react with convalescent phase antiserum from an -infected dog, and may be useful in the development of vaccines and serodiagnostics that are particularly effective for disease prevention and serodiagnosis.
Homologous 28-Kilodaltion Immunodominant Protein Genes Of Ehrlichia Canis And Uses Thereof
Homologous 28-Kilodaltion Immunodominant Protein Genes Of Ehrlichia Canis And Uses Thereof
US Patent:
2002011, Aug 22, 2002
Filed:
Jan 31, 2002
Appl. No.:
10/062624
Inventors:
David Walker - Galveston TX, US
Jere McBride - Galveston TX, US
Jere McBride - Galveston TX, US
International Classification:
C07H021/02, C07H021/04, C12N015/00, C12N015/09, C12N015/63, C12N015/70, C12N015/74
US Classification:
536/023100, 435/320100
Abstract:
The present invention is directed to the cloning, sequencing and expression of homologous immunoreactive 28-kDa protein genes, p28-1, -2, -3, -5, -6, -7, -9, from a polymorphic multiple gene family of Further disclosed is a multigene locus encoding all nine homologous 28-kDa protein genes of Recombinant 28-kDa proteins react with convalescent phase antiserum from an -infected dog, and may be useful in the development of vaccines and serodiagnostics that are particularly effective for disease prevention and serodiagnosis.
P153 And P156 Antigens For The Immunodiagnosis Of Canine And Human Ehrlichioses And Uses Thereof
P153 And P156 Antigens For The Immunodiagnosis Of Canine And Human Ehrlichioses And Uses Thereof
US Patent:
7204992, Apr 17, 2007
Filed:
Nov 4, 2003
Appl. No.:
10/701038
Inventors:
Jere W. McBride - League City TX, US
David H. Walker - Galveston TX, US
David H. Walker - Galveston TX, US
Assignee:
Clayton Foundation for Research - Houston TX
International Classification:
A61K 39/02
US Classification:
4242341, 4242821, 530350, 530820, 530825
Abstract:
Sequences encoding two immunoreactive glycoproteins were cloned from (p153 gene) and (p156 gene). These two glycoproteins are species-specific immunoreactive orthologs that are useful as subunit vaccines and for serologic and molecular diagnostics for and.
Immunoreactive 38-Kda Ferric Binding Protein Of And Uses Thereof
Immunoreactive 38-Kda Ferric Binding Protein Of And Uses Thereof
US Patent:
7722880, May 25, 2010
Filed:
Feb 25, 2005
Appl. No.:
11/066648
Inventors:
Jere W. McBride - League City TX, US
David H. Walker - Galveston TX, US
Christopher Kuyler Doyle - Bacliff TX, US
David H. Walker - Galveston TX, US
Christopher Kuyler Doyle - Bacliff TX, US
Assignee:
Research Development Foundation - Carson City NV
International Classification:
A61K 39/00, A61K 39/02, A61K 39/38, A61K 45/00, C12P 21/08
US Classification:
4241901, 4241841, 4241851, 4242341, 4242781, 424400, 424404, 5303884, 5303895, 930 10, 930200
Abstract:
The present invention is directed to the cloning, sequencing, expression, and characterization of an immunoreactive ferric binding protein (Fbp) (38-kDa) protein of encoded by a polynucleotide therefor. In particular embodiments, the protein is employed in an immunogenic composition, such as a vaccine. Methods to induce an immune reaction in an individual with compositions of the invention are provided.