DR. DAVID H. SACHS, M.D.
Osteopathic Medicine at 13 St, Boston, MA
License number
Massachusetts 57516
Category
Osteopathic Medicine
Type
Clinical & Laboratory Immunology
Address
Address
2
13Th St, Boston, MA 02466
77 Studio Rd, Newton, MA 02466
77 Studio Rd, Newton, MA 02466
Phone
(617) 726-4065
(617) 726-4067 (Fax)
(617) 244-5051
(617) 726-4067 (Fax)
(617) 244-5051
Personal information
See more information about DAVID H. SACHS at radaris.comName
Address
Phone
36 Ranger Rd, Natick, MA 01760
77 Studio Rd, Auburndale, MA 02466
1374 Trapelo Rd, Waltham, MA 02451
289 Davis Rd, Bedford, MA 01730
Organization information
See more information about DAVID H. SACHS at bizstanding.comDavid H Sachs
77 Studio Rd, Newton, MA 02466
Status:
Inactive
Industry:
Reviewer
Director:
Xeno Transplants Corporation Director, inactive
Professional information
See more information about DAVID H. SACHS at trustoria.com
Inbred Miniature Swine And Uses Thereof
Inbred Miniature Swine And Uses Thereof
US Patent:
6469229, Oct 22, 2002
Filed:
Aug 20, 1999
Appl. No.:
09/378684
Inventors:
David H. Sachs - Newton MA
Scott Arn - North Andover MA
Scott Arn - North Andover MA
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A01K 67027
US Classification:
800 17, 800 8, 800 21
Abstract:
The invention provides a swine which is homozygous for a major histocompatibility complex haplotype and at least 60% homozygous at all other genetic loci and such animal is propagatable, and a cell or an organ derived therefrom. The invention also provides a method for providing a swine which is homozygous at swine leukocyte antigens (SLA) A, B, C, DR, and DQ, and in which at least 60% of all other genetic loci are homozygous, as well as a method of inducing tolerance in a recipient mammal of a first species to a graft from a donor mammal of a second species.
Transgenic Swine Swine Cells Having Human Hla Genes
Transgenic Swine Swine Cells Having Human Hla Genes
US Patent:
6558663, May 6, 2003
Filed:
Dec 8, 1999
Appl. No.:
09/457177
Inventors:
Joerg Seebach - Boston MA
David H. Sachs - Newton MA
Harout DerSimonian - Wellesley MA
Christian LeGuern - Newton MA
David H. Sachs - Newton MA
Harout DerSimonian - Wellesley MA
Christian LeGuern - Newton MA
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61K 4800
US Classification:
424 9321, 424 932, 435325, 4353201, 800 8, 800 13, 800 17, 800 21
Abstract:
Methods of promoting tolerance and inhibiting NK cell mediated attack in a human recipient to a swine graft are disclosed The methods include introducing into the recipient a swine hematopoietic stem cell which has been transformed with a transgene encoding a human MHC class I protein that inhibits recipient NK cell mediated attack.
.Alpha.(1,3) Galactosyltransferase Negative Porcine Cells
.Alpha.(1,3) Galactosyltransferase Negative Porcine Cells
US Patent:
6153428, Nov 28, 2000
Filed:
Mar 26, 1996
Appl. No.:
8/621700
Inventors:
Kenth T. Gustafsson - Amersham, GB
David H. Sachs - Newton MA
David H. Sachs - Newton MA
Assignee:
BioTransplant, Inc. - Charlestown MA
International Classification:
C12N 500, C12N 1500, A61K 4800
US Classification:
435325
Abstract:
Transgenic swine in which the normal expression of. alpha. (1,3) galactosyltransferase is prevented in at least one organ of tissue type. The absence or inactivation of this enzyme prevents the production of carbohydrate moieties having the distinctive terminal Gal. alpha. 1-3Gal. beta. 1-4GlcNAc epitope that is a significant factor in xenogeneic, particularly human, transplant rejection of swine grafts.
Inbred Miniature Swine And Uses Thereof
Inbred Miniature Swine And Uses Thereof
US Patent:
2007003, Feb 8, 2007
Filed:
Oct 10, 2006
Appl. No.:
11/545230
Inventors:
David Sachs - Newton MA, US
Scott Arn - North Andover MA, US
Scott Arn - North Andover MA, US
International Classification:
A01K 67/027, C12N 5/06
US Classification:
800017000, 435325000
Abstract:
The invention provides a swine which is homozygous for a major histocompatibility complex haplotype and at least 60% homozygous at all other genetic loci and such animal is propagatable, and a cell or an organ derived therefrom. The invention also provides a method for providing a swine which is homozygous at swine leukocyte antigens (SLA) A, B, C, DR, and DQ, and in which at least 60% of all other genetic loci are homozygous, as well as a method of inducing tolerance in a recipient mammal of a first species to a graft from a donor mammal of a second species.
Allogeneic And Xenogeneic Transplantation
Allogeneic And Xenogeneic Transplantation
US Patent:
2006014, Jul 6, 2006
Filed:
Jun 13, 2005
Appl. No.:
11/151744
Inventors:
David Sachs - Newton MA, US
International Classification:
A61K 35/407
US Classification:
424093700
Abstract:
The invention provides methods for restoring or inducing imnmunocompetence, the methods including the step of introducing donor thymic tissue into the recipient. The invention also provides methods for inducing tolerance in a recipient including introducing donor thymic tissue into the recipient. The invention further provides methods of inducing tolerance including administering to the recipient a short course of help reducing treatment or administering a short course and methods of prolonging the acceptance of a graft by administering a short course of an immunosuppressant.
Transplantation And Graft-Versus-Host-Disease
Transplantation And Graft-Versus-Host-Disease
US Patent:
5843425, Dec 1, 1998
Filed:
Jun 5, 1995
Appl. No.:
8/461693
Inventors:
David H. Sachs - Newton MA
J. Scott Arn - North Andover MA
Thomas Lorf - Hardegsen/Gladebeck, DE
J. Scott Arn - North Andover MA
Thomas Lorf - Hardegsen/Gladebeck, DE
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
C12N 500, A61K 3900
US Classification:
424 931
Abstract:
A method of preparing swine donor tissue which includes hematopoietic stem cells and T cells for transplantation into a recipient mammal other than a swine. The method includes the swine donor tissue with an antibody which binds the epitope recognized by the mAb 2-6-15 monoclonal antibody. The binding facilitates depletion of T cells about as efficiently or more efficiently than does the mAb 2-6-15 monoclonal antibody and results in about the same or less depletion of stem cells as does the mAb 2-6-15 monoclonal antibody.
Allogeneic And Xenogeneic Transplantation
Allogeneic And Xenogeneic Transplantation
US Patent:
6911220, Jun 28, 2005
Filed:
Nov 9, 2000
Appl. No.:
09/710971
Inventors:
David H. Sachs - Newton MA, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61K035/26, A61K035/407, A61K048/00, C12N005/00
US Classification:
424580, 424553, 424 931, 424 933, 424 932, 424 9321, 4241301
Abstract:
The invention provides methods for restoring or inducing immunocompetence, the methods including the step of introducing donor thymic tissue into the recipient. The invention also provides methods for inducing tolerance in a recipient including introducing donor thymic tissue into the recipient. The invention further provides methods of inducing tolerance including administering to the recipient a short course of help reducing treatment or administering a short course and methods of prolonging the acceptance of a graft by administering a short course of an immunosuppressant.
Induced Tolerance To Xenografts
Induced Tolerance To Xenografts
US Patent:
6296846, Oct 2, 2001
Filed:
May 26, 1995
Appl. No.:
8/451210
Inventors:
David H. Sachs - Newton MA
A. Benedict Cosimi - Weston MA
Megan Sykes - Charlestown MA
A. Benedict Cosimi - Weston MA
Megan Sykes - Charlestown MA
Assignee:
The General Hospital - Massachusetts
International Classification:
A61K 4800, A61K 39395
US Classification:
424 9321
Abstract:
The invention features a method designed to lengthen the time an implanted organ (a xenograft) survives in a xenogeneic host prior to rejection. Preparation of the recipient for transplantation includes the following steps: First, the recipient is administered low dose radiation. Second, an antibody preparation that binds T cells and NK cells is injected into the recipient. Third, natural antibodies are absorbed from the recipient's blood by hemoperfusion of an organ of the donor species. Fourth, hematopoietic stromal tissue of the donor species is administered to the recipient. Fifth, donor hematopoietic stem cells are injected into the recipient. Finally, the xenograft organ is implanted into the recipient mammal. Best results are obtained when all steps are used in combination.
Dna Encoding Procine Interleukin-10
Dna Encoding Procine Interleukin-10
US Patent:
5624823, Apr 29, 1997
Filed:
Aug 30, 1993
Appl. No.:
8/114072
Inventors:
David H. Sachs - Newton MA
Christian A. Leguern - Newton MA
Megan Sykes - Charlestown MA
Gilles JF. Blancho - Cambridge MA
Christian A. Leguern - Newton MA
Megan Sykes - Charlestown MA
Gilles JF. Blancho - Cambridge MA
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
C12N 510, C12N 1524
US Classification:
435 6952
Abstract:
Purified DNA encoding porcine IL-10, porcine IL-10, and methods of inducing immunological tolerance and inhibiting graft versus host disease.
Multiple Administrations Of Umbilicus Derived Cells
Multiple Administrations Of Umbilicus Derived Cells
US Patent:
2009022, Sep 3, 2009
Filed:
Feb 28, 2008
Appl. No.:
12/039480
Inventors:
David H. Sachs - Auburndale MA, US
Christene Huang - Dover MA, US
Patricia S. Cho - Cambridge MA, US
Sicco Pompa - Chalfont PA, US
Christene Huang - Dover MA, US
Patricia S. Cho - Cambridge MA, US
Sicco Pompa - Chalfont PA, US
International Classification:
G01N 33/567
US Classification:
435 721
Abstract:
A method to determine the optimal administration protocol of allogeneic donor tissue to treat a disease in a human, using an animal model of human disease.