DR. DAVID H ROSMARIN, PH.D.
Social Work at 5 Ave, New York, NY

2006004, Feb 23, 2006

Oct 15, 2004

10/966321

David Rosmarin - New York NY, US
Zhiheng Pei - New York NY, US
Martin Blaser - New York NY, US
Sanjay Tyagi - Newark NJ, US

C12Q 1/68, C07H 21/04

435006000, 536024100

A nucleic acid probe for identifying a target nucleic acid sequence including a linker structure including a 5′ end and a 3′ end; 5′ marker mechanism for producing an identifying signal to the target nucleic acid sequence, wherein the 5′ marker mechanism is conjugated to the 5′ end of the linker structure; and 3′ marker mechanism for producing an identifying signal to a target nucleic acid sequence, wherein the 3′ marker mechanism is conjugated to the 3′ end of the linker structure and wherein identification of the target nucleic acid sequence occurs when the 5′ marker mechanism and 3′ marker mechanism are in close physical proximity to each other. A nucleic acid probe for identifying a target nucleic acid including a marker pair mechanism for producing an identification signal to identify a target nucleic acid sequence; and linker mechanism for linking the marker pair mechanism together. A biosensor including a fluorophore quencher pair; and a linker sequence for linking the fluorophore quencher pair. A probe for use in a polymerase chain reaction (PCR).