Inventors:
Robert J. Fallon - Chesterfield MO
Joseph W. Bulock - St. Peters MO
Steven P. Adams - St. Charles MO
David H. Perlmutter - Clayton MO
Assignee:
Washington University - St. Louis MO
International Classification:
C07K 706, A61K 3700
Abstract:
Novel short peptides of up to about 20 amino acid residues are disclosed that bind to the SEC receptor. These novel peptides preferably are pentapeptides which are synthetic analogs of a pentapeptide domain in the carboxy-terminal fragment of. alpha. sub. 1 -antitrypsin (amino acids 370-374, Phe-Val-Phe-Leu-Met [SEQ ID NO:2]). A preferred binding peptide is Phe-Val-Ala-Leu-Met [SEQ ID NO;6].