DAVID H LEE
Engineering in Cambridge, MA

License number
Massachusetts 50851
Issued Date
Jan 6, 2014
Expiration Date
Jun 30, 2018
Type
Mechanical Engineer
Address
Address
Cambridge, MA 02141
LicenseFiles verified this license of Nov 24, 2016 at the Mass.gov - Consumer Affairs and Business Regulation.

Professional information

David Lee Photo 1

Anti-Hunger Advocate, Community Affairs And Government Relations Specialist, And Arm Wrestling Champion
Position:
Program Development Specialist at Feeding America, Board of Directors at Outpost Natural Foods Cooperative
Location:
Milwaukee, Wisconsin
Industry:
Nonprofit Organization Management
Work:
Feeding America since Jun 2012 - Program Development Specialist Outpost Natural Foods Cooperative - Milwaukee, WI since Nov 2012 - Board of Directors Feeding America Oct 2010 - Jun 2012 - Director of Government Relations and Advocacy Hunger Task Force 2010 - 2010 - Program Developer The Jewish Federation 2002 - 2010 - Special Projects JHK Productions Oct 1997 - Jan 2008 - Entertainment Industry Professional Split.Id Theater Company Jul 2003 - Apr 2005 - Writer/Director Consumer Dynamics 2000 - 2000 - Account Coordinator Proxy Monitor - New York, NY 1999 - 2000 - Y2K Compliance Consultant Grafton Street - Cambridge, MA 1997 - 1998 - Senior Chef
Education:
Vassar College 1993 - 1997
AB, Film and Drama San Francisco School of the Arts 1989 - 1993
Drama
Skills:
Non-profits, Grant Administration, Fundraising, Program Development, Community Outreach, Grants, Volunteer Management, Grant Writing, Philanthropy, Community Development, Research, Board Development, Program Evaluation, Public Policy, Nonprofits, Program Management, Public Speaking
Languages:
Mandarin Chinese, Spanish
Awards:
Wisconsin Political Leaders Fellow
Center for Progressive Leadership
American Express NGen Fellow
Independent Sector
3rd Place, Men's Lightweight Right Hand
Monster Arm Wrestling Championship, Iowa State Fair
Chair, Vassar College Class of 1997 Reunion

David Lee Photo 2

Phd Student, Chemistry &Amp; Chemical Biology At Harvard University
Position:
PhD Student, Chemistry & Chemical Biology at Harvard University
Location:
Cambridge, Massachusetts
Industry:
Research
Work:
Harvard University - PhD Student, Chemistry & Chemical Biology University of Pennsylvania - Greater Philadelphia Area Jan 2010 - May 2012 - Undergraduate Research Assistant Talent100 Education Dec 2007 - Aug 2009 - Tutor & Course Developer
Education:
University of Pennsylvania 2008 - 2012
Bachelor of Arts (B.A.), Physics & Biochemistry University of Pennsylvania 2008 - 2012
Master of Science (M.S.), Chemistry
Skills:
Microsoft Excel, Matlab
Languages:
Chinese (Mandarin)

David Lee Photo 3

David Lee - Cambridge, MA
Work:
Cambridge Athletic Club
Group Fitness Manager MIT Zesiger Sports and Fitness Center
Personal Trainer MIT Zesiger Sports and Fitness Center - Cambridge, MA
Personal Trainer MIT Zesiger Sports and Fitness Center - Boston, MA
Personal Trainer
Education:
Berklee College of Music
Professional Diploma in Film Scoring Ohio State University
Music Composition

David Lee Photo 4

Weakly Basic 2-Nitroimidazoles For The Non-Invasive Detection Of Tissue Hypoxia

US Patent:
2008008, Apr 10, 2008
Filed:
Oct 6, 2006
Appl. No.:
11/544698
Inventors:
James A. Raleigh - Chapel Hill NC, US
David Y-W Lee - Cambridge MA, US
Xiaoshen Ji - Acton MA, US
International Classification:
A61K 51/00
US Classification:
424 111, 534 11
Abstract:
The present invention incorporates weakly basic substituents (pKa about 8 or greater) such as pyrrolidine, piperidine, piperazine and azapane moieties in halogenated 2-nitromidazoles as a major improvement over prior art for the non-invasive detection of cellular hypoxia in normal and malignant tissues. The invention features the use of [18F] positron emission tomography, [19F] magnetic resonance spectroscopy, and [19F] magnetic resonance imaging. Improvements over prior art compounds are six-fold. 1) Salts of weakly basic reagents are highly water-soluble which facilitates administration. 2) Unreacted reagents are rapidly cleared from systemic circulation thereby decreasing background noise. 3) Reagents with weakly basic substituents are concentrated in tissue ˜3 fold above plasma levels thereby increasing binding intensity and enhancing signal detection. 4) Conjugate bases of weakly basic reagents have intermediate octanol-water partition coefficients that facilitate their penetration into all tissues including brain. 5) Cellular adducts of reagents containing weakly basic substituents are more stable than reagents of prior art. 6) Reagents with weakly basic substituents are effective for the detection of transient hypoxia in solid tissue.

David Lee Photo 5

11.Beta.-Aryl-17, 17-Spirothiolane-Substituted Steroids

US Patent:
6043235, Mar 28, 2000
Filed:
Jul 21, 1999
Appl. No.:
9/357923
Inventors:
C. Edgar Cook - Staunton VA
Rupa S. Shetty - West Chester PA
John A. Kepler - Raleigh NC
David Y.-W. Lee - Cambridge MA
Assignee:
Research Triangle Institute - Research Triangle Park NC
International Classification:
A61K 3158, C07J 3300
US Classification:
514173
Abstract:
The invention is directed to 11. beta. -aryl-17,17-spirothiolane substituted steroid compounds of formula (I) exhibiting binding to the progestin receptor. ##STR1## Also disclosed are methods of using and process of making the compounds.

David Lee Photo 6

Salvinorin Derivatives And Uses Thereof

US Patent:
7629475, Dec 8, 2009
Filed:
Mar 14, 2005
Appl. No.:
11/079825
Inventors:
Cécile Béquin - Lexington MA, US
William A. Carlezon - Lincoln MA, US
Bruce M. Cohen - Lexington MA, US
Minsheng He - Allston MA, US
David Yue-Wei Lee - Cambridge MA, US
Michele R. Richards - Mansfield MA, US
Assignee:
The McLean Hospital Corporation - Belmont MA
International Classification:
C07D 311/78
US Classification:
549280
Abstract:
The invention features salvinorin compositions that are selective for kappa opioid receptors; methods of treating mania by using a selective kappa receptor agonist; and methods of treating mood disorders, such as depressive disorders and manic disorders, using salvinorin compositions.

David Lee Photo 7

Isoflavone Glycosides As Peroxisome Proliferator-Activated Receptor-Alpha Modulator

US Patent:
2009009, Apr 16, 2009
Filed:
Oct 16, 2007
Appl. No.:
11/872771
Inventors:
Hong Wang - Somerville MA, US
David Y-W Lee - Cambridge MA, US
International Classification:
A61K 31/7048, C07H 3/02, A61P 3/04
US Classification:
514 23, 536 111
Abstract:
A method of treating or preventing diseases related to modulation of PPAR-α in comprising administering to a human or other mammals in need of such treatment an effective amount of plant material derived from plants of the genera

David Lee Photo 8

Methods And Compositions For The Use Of Sargassum Fusiforme For The Inhibition Of Hiv-1 Infection

US Patent:
2010024, Sep 30, 2010
Filed:
May 23, 2008
Appl. No.:
12/601072
Inventors:
David Yue-wei Lee - Cambridge MA, US
Mario Canki - Gulderland NY, US
International Classification:
A61K 36/03, A61P 31/18, A61P 31/22, A61K 31/20, A61K 31/201, C07C 57/03, C07C 53/00
US Classification:
42419517, 514558, 514560, 554224, 554223, 554 1
Abstract:
The methods, kits, articles, and compositions of the invention feature a natural product (e.g., ), an extract thereof, and fatty acid components of the extract (e.g., palmitic acid) for the treatment of a viral infection, e.g., HIV or herpes. The natural products used in the methods and compositions of the invention include brown algae, specifically algae of the species. The algae, extracts thereof, specific components of the extract, and related compounds of the invention may be used to treat or prevent HIV and herpes infections.

David Lee Photo 9

Hypoxia-Selective, Weakly Basic 2-Nitroimidazole Delivery Agents And Methods Of Use Thereof

US Patent:
8518371, Aug 27, 2013
Filed:
Nov 29, 2010
Appl. No.:
12/955720
Inventors:
David Y-W Lee - Cambridge MA, US
James A. Raleigh - Chapel Hill NC, US
Assignee:
Natural Pharmacia International, Inc. - Burlington MA
International Classification:
A61K 51/00, A61M 36/14
US Classification:
424 189, 424 111, 424 165, 424 181, 424 185, 424 91, 424 94, 514183, 544224
Abstract:
The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or chelating groups. In particular, the invention provides 2-nitroimidazole compounds containing a cluster of boron atoms for use in boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat hypoxic conditions, including, e. g. , cancer, inflammation, and ischemia. The weakly basic 2-nitroimidazole compounds target to hypoxic tissue and provide increased tissue concentration overall.

David Lee Photo 10

Salvinorin Derivatives And Uses Thereof

US Patent:
2007021, Sep 13, 2007
Filed:
Sep 29, 2006
Appl. No.:
11/540921
Inventors:
Cecile Beguin - Lexington MA, US
William Carlezon - Lincoln MA, US
Bruce Cohen - Lexington MA, US
Minsheng He - Allston MA, US
David Lee - Cambridge MA, US
Michele Richards - Edmonton, CA
International Classification:
A61K 31/366, C07D 407/04
US Classification:
514455000, 549280000
Abstract:
The invention features salvinorin compositions that are selective for kappa opioid receptors; methods of treating mania by using a selective kappa receptor agonist; and methods of treating mood disorders, such as depressive disorders and manic disorders, using salvinorin compositions.

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