DAVID H HSU, MD
Anesthesiologist Assistant at Imperial Hwy, Lynwood, CA

6818439, Nov 16, 2004

Dec 30, 1997

09/001039

Douglas J. Jolly - Leucadia CA
Stephen Chang - Poway CA
James G. Respess - Pacific Beach CA
Nicholas J. DePolo - Solano Beach CA
David Chi-Tang Hsu - San Diego CA
Carlos E. Ibanez - San Diego CA
Judith Greengard - San Diego CA
Lee Will - Carlsbad CA

Chiron Corporation - Emeryville CA

C12N 15867

4353201, 4352351, 435 691, 435 696, 530350, 530384, 536 231, 536 235

Methods are provided for obtaining measurable levels of a protein, nucleic acid molecule, or enzymatic product in a bodily fluid or cells of a human, comprising the step of administering to a human a recombinant retroviral preparation having a titer on HT1080 cells of greater than 10 cfu/ml, wherein the recombinant retroviral preparation is capable of directing the expression of a protein, nucleic acid molecule, or enzyme which generates an enzymatic product, such that measurable levels of the protein, nucleic acid molecule, or enzymatic product may be obtained in the bodily fluid or cells of the human.

5681746, Oct 28, 1997

Dec 30, 1994

8/366851

Mordechai Bodner - San Diego CA
Nicholas J. De Polo - Solana Beach CA
Stephen Chang - Poway CA
David Chi-Tang Hsu - San Diego CA
James G. Respess - San Diego CA

Chiron Viagene, Inc.

C12N 500, C12N 1563, C07H 2104

435350

Retroviral vectors for directing expression of full length factor VIII in transduced host cells, plasmids encoding the same, and host cells transformed, transfected, or transduced therewith are disclosed. Also disclosed are retroviral particles comprising such retrovital vectors, as are methods for making such particles in suitable packaging cells. Retroviral particles so produced may be amphotropic, ecotropic, polytropic, or xenotropic; alternatively, they may comprise chimeric or hybrid envelope proteins to alter host range. Also described are retrovital particles comprising retroviral vectors for directing full length factor VIII expression which are complement resistant. Pharmaceutical compositions comprising retrovital particles of the invention are also disclosed, as are methods of treating mammals, particularly humans, afflicted with hemophilia.

2002006, Jun 6, 2002

Mar 1, 2001

09/797518

Julie Johnston - Hockessin DE, US
Sybille Sauter - Del Mar CA, US
David Hsu - San Diego CA, US
Philip Sheridan - San Diego CA, US
Stephen Hardy - San Francisco CA, US
Thomas Dubensky - Piedmont CA, US
Jiing-Kuan Yee - Arcadia CA, US

CHIRON CORPORATION

C12N007/01, C12N015/867, C07H021/04, C07K001/00, C12N015/74, C12N015/63

435/235100, 435/456000, 530/826000, 536/023720, 536/024100, 435/320100

Disclosed are gene therapy vectors based upon the feline immunodeficiency virus, as well as related packaging cell lines, methods for production, and methods of use.

2002004, Apr 25, 2002

Jan 15, 1999

09/231235

JULIE C. JOHNSTON - WILMINGTON DE, US
SYBILLE L. SAUTER - DEL MAR CA, US
DAVID CHI-TANG HSU - SAN DIEGO CA, US
PHILIP LEE SHERIDAN - SAN DIEGO CA, US
STEPHEN F. HARDY - SAN FRANCISCO CA, US
THOMAS W. DUBENSKY - PIEDMONT CA, US
JIING-KUAN YEE - DEL MAR CA, US

C12P013/14, C12N007/00, C12N007/01

435/235100

Disclosed are gene therapy vectors based upon the feline immunodeficiency virus, as well as related packaging cell lines, methods for production, and methods of use.

2003010, Jun 5, 2003

Jun 1, 2001

09/872696

Julie Johnston - Wilmington DE, US
Sybille Sauter - Del Mar CA, US
David Hsu - San Diego CA, US
Philip Sheridan - San Diego CA, US
Stephen Hardy - San Francisco CA, US
Thomas Dubensky - Piedmont CA, US
Jiing-Kuan Yee - Del Mar CA, US

A61K039/12, C12N007/00, C12N007/01, C12N015/00, C12N015/09, C12N015/63, C12N015/70, C12N015/74, C12N005/00, C12N005/02

435/320100, 435/235100, 435/325000, 424/199100

Disclosed are gene therapy vectors based upon the feline immunodeficiency virus, as well as related packaging cell lines, methods for production, and methods of use.