David H Dreyfus
Physician at Norton Pkwy, New Haven, CT
License number
Colorado 33246
Issued Date
Jan 20, 1994
Renew Date
May 31, 2001
Expiration Date
May 31, 2001
Type
Physician
Address
Address
488 Norton Pkwy, New Haven, CT 06511
Professional information
Nuclease Resistant External Guide Sequences For Treating Inflammatory And Viral Related Respiratory Diseases
US Patent:
2011019, Aug 11, 2011
Filed:
Apr 4, 2011
Appl. No.:
13/066021
Inventors:
David H. Dreyfus - New Haven CT, US
Assignee:
Yale University - New Haven CT
International Classification:
A61K 31/7088, A61P 29/00, A61P 11/00
US Classification:
514 44 A
Abstract:
External Guide Sequence (EGS) are described that target proteins required for generation and modification of the immunoglobulin and T-cell repertoire that are useful for treatment or prevention of inflammatory or related diseases. Formulations suitable for administration of an EGS for treatment of inflammatory or related disease are described. The formulations may be administered via inhalation, injection, or orally. The formulations may be in the form of an ointment, lotion, cream, gel, drop, suppository, spray, liquid, powder, granule, solution, suspension, capsule, or tablet. Methods of treating inflammatory or related diseases by administering an effective amount of an EGS in a pharmaceutically acceptable carrier are also described. In preferred embodiments, the disease is asthma, allergic rhinitis, food allergies, atopic skin disease such as eczema, IL-4 and/or IL-13 dependent malignancies, IL-4 and/or IL-13 dependent autoimmune diseases, atopic diseases, the flu, and diseases caused by IL-4 dependent replication of viruses.
Nuclease Resistant External Guide Sequences For Treating Inflammatory And Viral Related Respiratory Diseases
US Patent:
7928216, Apr 19, 2011
Filed:
Apr 29, 2005
Appl. No.:
11/118875
Inventors:
David H. Dreyfus - New Haven CT, US
Assignee:
Yale University - New Haven CT
International Classification:
C07H 21/04, A61K 31/715
US Classification:
536 245, 514 44
Abstract:
External Guide Sequence (EGS) are described that target proteins required for generation and modification of the immunoglobulin and T-cell repertoire that are useful for treatment or prevention of inflammatory or related diseases. Formulations suitable for administration of an EGS for treatment of inflammatory or related disease are described. The formulations may be administered via inhalation, injection, or orally. The formulations may be in the form of an ointment, lotion, cream, gel, drop, suppository, spray, liquid, powder, granule, solution, suspension, capsule, or tablet. Methods of treating inflammatory or related diseases by administering an effective amount of an EGS in a pharmaceutically acceptable carrier are also described. In preferred embodiments, the disease is asthma, allergic rhinitis, food allergies, atopic skin disease such as eczema, IL-4 and/or IL-13 dependent malignancies, IL-4 and/or IL-13 dependent autoimmune diseases, atopic diseases, the flu, and diseases caused by IL-4 dependent replication of viruses.
Targeting Of Rna With External Guide Sequences
US Patent:
2010029, Nov 18, 2010
Filed:
Aug 22, 2008
Appl. No.:
12/671498
Inventors:
David H. Dreyfus - New Haven CT, US
Lucy Y. Ghoda - San Francisco CA, US
Lucy Y. Ghoda - San Francisco CA, US
International Classification:
C40B 30/06, C07H 21/00, C12N 15/64, C12N 15/63, C40B 40/08, C12N 1/21, C12N 5/10
US Classification:
506 10, 536 231, 435440, 4353201, 506 17, 4352523, 435419, 435348
Abstract:
The present disclosure provides compositions and methods for modulating gene expression by using EGS to target miRNA. Another aspect of the present disclosure is the use of EGS to target mitochondrial RNA. MiRNA targets may include immature or mature forms of miRNA, such as miRNA overexpressed in diseases such as cancer.
Use Of T-Loop In Trans-Splicing Polynucleotides
US Patent:
2011023, Sep 29, 2011
Filed:
Oct 22, 2009
Appl. No.:
13/121399
Inventors:
David H. Dreyfus - New Haven CT, US
Lucy Y Ghoda - San Francisco CA, US
Bradford S. Goodwin - San Mateo CA, US
Lucy Y Ghoda - San Francisco CA, US
Bradford S. Goodwin - San Mateo CA, US
International Classification:
H04L 12/26
US Classification:
370235
Abstract:
A method of regulating data flow in a wireless communication network includes: collecting data regarding dynamic loading of sector-carrier pairs (pilots) in communication sectors of the wireless communication network; obtaining data rates for data flows of the pilots to access terminals within the wireless communication network; determining one or more pilots to use for conveying data in the wireless communication network based on the data rates and the dynamic loading; and altering data flow over the pilots by at least one of changing a data rate over at least one of the pilots or changing a combination of pilots used by the wireless communication network for conveying data to increase total data flow.