Inventors:
Mark J. Nuell - Ellicott City MD
J. Keith McClung - Ardmore OK
David A. Stewart - Baltimore MD
David B. Danner - Columbia MD
Assignee:
The United States of America as represented by the Department of Health
and Human Services - Washington DC
International Classification:
C12N 1512, C12N 1563, C12N 121, C07K 1447
Abstract:
The subject invention relates to a novel mammalian antiproliferative protein, prohibitin, and uses thereof. For example, prohibitin may be utilized in the treatment of diseases involving excess cellular replication, such as cancer, or in the treatment of conditions involving an insufficient amount of cellular replication, such as impaired tissue regeneration.