Inventors:
Brett C. Bookser - San Diego CA, US
Qun Dang - San Diego CA, US
Tony S. Gibson - San Diego CA, US
Hongjian Jiang - San Diego CA, US
De Michael Chung - Rowland Heights CA, US
Jianming Bao - Princeton NJ, US
Jinlong Jiang - Scotch Plains NJ, US
Andy Kassick - Scotch Plains NJ, US
Ahmet Kekec - Hoboken NJ, US
Ping Lan - Dayton NJ, US
Huagang Lu - Plainsboro NJ, US
Gergely M. Makara - Budapest, HU
F. Anthony Romero - Westfield NJ, US
Iyassu Sebhat - Jersey City NJ, US
David Wilson - Brooklyn NY, US
Dariusz Wodka - Monmouth Junction NJ, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 31/4184, C07D 235/26, C07D 235/28, C07D 235/30
Abstract:
Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.