Inventors:
Mark Totoritis - Rancho Santa Fe CA, US
Timothy Mark Shaw - Hertfordshire, GB
Sunil Agarwal - Corte Madera CA, US
David Yocum - San Mateo CA, US
Ariella Kelman - Hillsborough CA, US
International Classification:
A61K 39/395, A61P 19/02, A61P 37/00, A61B 10/00
Abstract:
Methods of treating joint damage in a subject eligible for treatment are provided involving administering an antagonist that binds to a B-cell surface marker, such as CD20 antibody, to the subject in an amount effective to slow progression of the joint damage as measured by radiography. Further provided are articles of manufacture useful for such methods.