DAVID EDWARD OTT
Pilots at Burnt Hickory Cir, Frederick, MD
License number
Maryland A5174768
Issued Date
Mar 2016
Expiration Date
Mar 2018
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
8604 Burnt Hickory Cir, Frederick, MD 21704
Professional information
Retrovirus-Like Particles And Retroviral Vaccines
US Patent:
2007009, May 3, 2007
Filed:
Apr 27, 2006
Appl. No.:
11/413614
Inventors:
David Ott - Frederick MD, US
Dexter Poon - Rockville MD, US
Robert Gorelick - Rockville MD, US
Dexter Poon - Rockville MD, US
Robert Gorelick - Rockville MD, US
International Classification:
C12P 19/34, C12N 5/06, C12N 5/16
US Classification:
435091100, 435345000
Abstract:
The invention relates to retrovirus-like particles having an altered nucleocapsid domain that inhibits packaging of genomic RNA into the retrovirus-like particle, and a protease having reduced enzymatic activity. The invention also provides nucleic acid constructs that encode the retrovirus-like particles. Also provided are immunological compositions, vaccines, and DNA vaccines containing the retrovirus-like particles and nucleic acid constructs that can be used to immunize a mammal against infection by a retrovirus. Methods to produce retrovirus-like particles are also provided.