DAVID EDWARD KAPLAN
Medical Practice in Delaware
License number
Pennsylvania MD073465L
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Delaware
Media, PA 19063
Media, PA 19063
Professional information
Expansion Of Interferon-Gamma-Producing T-Cells Using Glypican-3 Peptide Library
US Patent:
2013021, Aug 22, 2013
Filed:
Feb 21, 2013
Appl. No.:
13/773090
Inventors:
The Trustees of the University of Pennsylvania - , US
Government of the United States of America as Represented by the Secretary of the Department of Veteran - , US
David E. Kaplan - Media PA, US
Government of the United States of America as Represented by the Secretary of the Department of Veteran - , US
David E. Kaplan - Media PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
Veteran - Washington DC
Veteran - Washington DC
International Classification:
C12N 5/0783, C07K 14/725
US Classification:
4353723, 536 235
Abstract:
The present invention encompasses a method for expanding an antigen specific T cell from a population of cells. The method of the present invention comprises contacting a population of cells with an MHC restricted antigenic glypican-3 peptide. In some instances, the T cell is expanded using monocyte-derived dendritic cells and defined MHC restricted antigenic glypican-3 peptides. In one embodiment, high-affinity antigen-specific T-cell receptors (TCRs) can be cloned from the antigen specific T cell.