Inventors:
Joel V. Weinstock - Iowa City IA, US
David E. Elliott - Iowa City IA, US
Assignee:
University of Iowa, The Research Foundation - Iowa City IA
International Classification:
A61K 49/00, A61K 39/00, A61P 37/00, A61P 37/04, A61P 29/00, A61K 35/56, C12Q 1/02
US Classification:
424 91, 4242651, 424520, 435 29
Abstract:
The invention relates to a method of treating an excessive immune response including an aberrant/enhanced Th1 response by administering a helminthic parasite preparation in an amount sufficient to reduce the excessive immune response in an individual. This invention is generally directed to autoimmune diseases which involve an excessive immune response or an aberrant/enhanced Th1 response. More specifically, the present invention is directed to the treatment of Crohn's disease and ulcerative colitis, both known as IBD. While the present invention discloses specific information about the treatment of IBD, the disclosure is in no way limiting. Additionally, rheumatoid arthritis, type 1 diabetes mellitus, lupus erythematosis, sarcoidosis, multiple sclerosis, autoimmune thyroiditis, allergic rhinitis, colon polyps/colon cancer and asthma can be treated by the methods and compositions disclosed therein.