David Dell Morrissey
Physician at Arapahoe Ave, Boulder, CO
License number
Colorado 37667
Issued Date
Mar 25, 1999
Renew Date
May 1, 2015
Expiration Date
Apr 30, 2017
Type
Physician
Address
Address
4745 Arapahoe Ave #130, Boulder, CO 80303
Professional information
Rna Inteference Mediated Inhibition Of Hepatitis C Virus (Hvc) Gene Expression Using Short Interfering Nucleic Acid (Sina)
US Patent:
2008020, Aug 28, 2008
Filed:
Aug 25, 2006
Appl. No.:
11/510872
Inventors:
James McSwiggen - Boulder CO, US
David Morrissey - Boulder CO, US
Roberto Guerciolini - Boulder CO, US
Chandra Vargeese - Broomfield CO, US
Vasant Jadhav - Longmont CO, US
David Morrissey - Boulder CO, US
Roberto Guerciolini - Boulder CO, US
Chandra Vargeese - Broomfield CO, US
Vasant Jadhav - Longmont CO, US
Assignee:
Sirna Therapeutics, Inc. - San Francisco CA
International Classification:
A61K 31/713
US Classification:
514 44
Abstract:
The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity. The present invention is also directed to compounds, compositions, and methods relating to traits, diseases and conditions that respond to the modulation of expression and/or activity of genes involved in gene expression pathways or other cellular processes that mediate the maintenance or development of such traits, diseases and conditions. Specifically, the invention relates to double stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against gene expression, including cocktails of such small nucleic acid molecules and lipid nanoparticle (LNP) formulations of such small nucleic acid molecules. The present invention also relates to small nucleic acid molecules, such as siNA, siRNA, and others that can inhibit the function of endogenous RNA molecules, such as endogenous micro-RNA (miRNA) (e.g, miRNA inhibitors) or endogenous short interfering RNA (siRNA), (e.g., siRNA inhibitors) or that can inhibit the function of RISC (e.g., RISC inhibitors), to modulate gene expression by interfering with the regulatory function of such endogenous RNAs or proteins associated with such endogenous RNAs (e.g., RISC), including cocktails of such small nucleic acid molecules and lipid nanoparticle (LNP) formulations of such small nucleic acid molecules. Such small nucleic acid molecules and are useful, for example, in providing compositions to prevent, inhibit, or reduce diseases, traits and conditions that are associated with gene expression or activity in a subject or organism.
Rna Interference Mediated Inhibition Of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (Sina)
US Patent:
2006029, Dec 28, 2006
Filed:
Aug 4, 2006
Appl. No.:
11/499533
Inventors:
James McSwiggen - Boulder CO, US
Bharat Chowrira - Louisville CO, US
Leonid Beigelman - Brisbane CA, US
Dennis Macejak - Arvada CO, US
Shawn Zinnen - Denver CO, US
Pamela Pavco - Lafayette CO, US
Peter Haeberli - Berthoud CO, US
David Morrissey - Boulder CO, US
Kathy Fosnaugh - Boulder CO, US
Sharon Jamison - Boulder CO, US
Nassim Usman - Lafayette CO, US
James Thompson - Lafayette CO, US
Chandra Vargeese - Broomfield CO, US
Weimin Wang - Superior CO, US
Tongqian Chen - Longmont CO, US
Narendra Vaish - Denver CO, US
Bharat Chowrira - Louisville CO, US
Leonid Beigelman - Brisbane CA, US
Dennis Macejak - Arvada CO, US
Shawn Zinnen - Denver CO, US
Pamela Pavco - Lafayette CO, US
Peter Haeberli - Berthoud CO, US
David Morrissey - Boulder CO, US
Kathy Fosnaugh - Boulder CO, US
Sharon Jamison - Boulder CO, US
Nassim Usman - Lafayette CO, US
James Thompson - Lafayette CO, US
Chandra Vargeese - Broomfield CO, US
Weimin Wang - Superior CO, US
Tongqian Chen - Longmont CO, US
Narendra Vaish - Denver CO, US
Assignee:
Sirna Therapeutics, Inc. - San Francisco CA
International Classification:
A61K 48/00, C07H 21/02
US Classification:
514044000, 536023100
Abstract:
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
Rna Interference Mediated Inhibition Of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (Sina)
US Patent:
2009002, Jan 22, 2009
Filed:
Apr 17, 2008
Appl. No.:
12/105010
Inventors:
James McSwiggen - Boulder CO, US
Bharat Chowrira - Louisville CO, US
Leonid Beigelman - Longmont CO, US
Dennis Macejak - Arvada CO, US
Shawn Zinnen - Denver CO, US
Pamela Pavco - Lafayette CO, US
Peter Haeberli - Berthoud CO, US
David Morrissey - Boulder CO, US
Kathy Fosnaugh - Longmont CO, US
Sharon Jamison - Boulder CO, US
Nassim Usman - Lafayette CO, US
James Thompson - Lafayette CO, US
Chandra Vargeese - Blue Bell PA, US
Weimin Wang - Newton PA, US
Tongqian Chen - Longmont CO, US
Narendra Vaish - Boulder CO, US
Bharat Chowrira - Louisville CO, US
Leonid Beigelman - Longmont CO, US
Dennis Macejak - Arvada CO, US
Shawn Zinnen - Denver CO, US
Pamela Pavco - Lafayette CO, US
Peter Haeberli - Berthoud CO, US
David Morrissey - Boulder CO, US
Kathy Fosnaugh - Longmont CO, US
Sharon Jamison - Boulder CO, US
Nassim Usman - Lafayette CO, US
James Thompson - Lafayette CO, US
Chandra Vargeese - Blue Bell PA, US
Weimin Wang - Newton PA, US
Tongqian Chen - Longmont CO, US
Narendra Vaish - Boulder CO, US
Assignee:
SIRNA THERAPEUTICS, INC. - San Francisco CA
International Classification:
A61K 31/7088, C07H 21/00, A61P 43/00
US Classification:
514 44, 536 231
Abstract:
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
Rna Interference Mediated Inhibition Of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (Sina)
US Patent:
2004019, Sep 30, 2004
Filed:
May 23, 2003
Appl. No.:
10/444853
Inventors:
James McSwiggen - Boulder CO, US
Bharat Chowrira - Louisville CO, US
Leonid Beigelman - Longmont CO, US
Dennis Macejak - Arvada CO, US
Shawn Zinnen - Denver CO, US
Pamela Pavco - Lafayette CO, US
Peter Haeberli - Berthoud CO, US
David Morrissey - Boulder CO, US
Kathy Fosnaugh - Boulder CO, US
Sharon Jamison - Boulder CO, US
Nassim Usman - Lafayette CO, US
James Thompson - Lafayette CO, US
Chandra Vargeese - Thorton CO, US
Weimin Wang - Superior CO, US
Tongqian Chen - Longmont CO, US
Narendra Vaish - Boulder CO, US
Bharat Chowrira - Louisville CO, US
Leonid Beigelman - Longmont CO, US
Dennis Macejak - Arvada CO, US
Shawn Zinnen - Denver CO, US
Pamela Pavco - Lafayette CO, US
Peter Haeberli - Berthoud CO, US
David Morrissey - Boulder CO, US
Kathy Fosnaugh - Boulder CO, US
Sharon Jamison - Boulder CO, US
Nassim Usman - Lafayette CO, US
James Thompson - Lafayette CO, US
Chandra Vargeese - Thorton CO, US
Weimin Wang - Superior CO, US
Tongqian Chen - Longmont CO, US
Narendra Vaish - Boulder CO, US
International Classification:
A61K048/00, C07H021/04
US Classification:
514/044000, 536/023100
Abstract:
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
Rna Interference Mediated Inhibition Of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (Sina)
US Patent:
2006021, Sep 28, 2006
Filed:
Feb 21, 2006
Appl. No.:
11/358932
Inventors:
James McSwiggen - Boulder CO, US
Bharat Chowrira - Louisville CO, US
Leonid Beigelman - Longmont CO, US
Dennis Macejak - Arvada CO, US
Shawn Zinnen - Denver CO, US
Pamela Pavco - Lafayette CO, US
Peter Haeberli - Berthoud CO, US
David Morrissey - Boulder CO, US
Kathy Fosnaugh - Boulder CO, US
Sharon Jamison - Boulder CO, US
Nassim Usman - Lafayette CO, US
James Thompson - Lafayette CO, US
Chandra Vargeese - Thorton CO, US
Weimin Wang - Superior CO, US
Tongqian Chen - Longmont CO, US
Narendra Vaish - Boulder CO, US
Bharat Chowrira - Louisville CO, US
Leonid Beigelman - Longmont CO, US
Dennis Macejak - Arvada CO, US
Shawn Zinnen - Denver CO, US
Pamela Pavco - Lafayette CO, US
Peter Haeberli - Berthoud CO, US
David Morrissey - Boulder CO, US
Kathy Fosnaugh - Boulder CO, US
Sharon Jamison - Boulder CO, US
Nassim Usman - Lafayette CO, US
James Thompson - Lafayette CO, US
Chandra Vargeese - Thorton CO, US
Weimin Wang - Superior CO, US
Tongqian Chen - Longmont CO, US
Narendra Vaish - Boulder CO, US
Assignee:
Sirna Therapeutics, Inc. - Boulder CO
International Classification:
A61K 48/00, C07H 21/02, C07F 9/6512
US Classification:
514044000, 536023100, 544243000, 536025300
Abstract:
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
Rna Interference Mediated Inhibition Of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (Sina)
US Patent:
2006029, Dec 28, 2006
Filed:
Aug 4, 2006
Appl. No.:
11/499521
Inventors:
James McSwiggen - Boulder CO, US
Bharat Chowrira - Louisville CO, US
Leonid Beigelman - Brisbane CA, US
Dennis Macejak - Arvada CO, US
Shawn Zinnen - Denver CO, US
Pamela Pavco - Lafayette CO, US
Peter Haeberli - Berthoud CO, US
David Morrissey - Boulder CO, US
Kathy Fosnaugh - Boulder CO, US
Sharon Jamison - Boulder CO, US
Nassim Usman - Lafayette CO, US
James Thompson - Lafayette CO, US
Chandra Vargeese - Broomfield CO, US
Weimin Wang - Superior CO, US
Tongqian Chen - Longmont CO, US
Narendra Vaish - Denver CO, US
Bharat Chowrira - Louisville CO, US
Leonid Beigelman - Brisbane CA, US
Dennis Macejak - Arvada CO, US
Shawn Zinnen - Denver CO, US
Pamela Pavco - Lafayette CO, US
Peter Haeberli - Berthoud CO, US
David Morrissey - Boulder CO, US
Kathy Fosnaugh - Boulder CO, US
Sharon Jamison - Boulder CO, US
Nassim Usman - Lafayette CO, US
James Thompson - Lafayette CO, US
Chandra Vargeese - Broomfield CO, US
Weimin Wang - Superior CO, US
Tongqian Chen - Longmont CO, US
Narendra Vaish - Denver CO, US
Assignee:
Sirna Therapeutics, Inc. - San Francisco CA
International Classification:
A61K 48/00, C07H 21/02, C07F 9/6512
US Classification:
514044000, 536023100, 544243000, 544244000
Abstract:
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
Rna Interference Mediated Inhibition Of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (Sina)
US Patent:
2006029, Dec 28, 2006
Filed:
Aug 11, 2006
Appl. No.:
11/502885
Inventors:
James McSwiggen - Boulder CO, US
Bharat Chowrira - Louisville CO, US
Leonid Beigelman - Brisbane CA, US
Dennis Macejak - Arvada CO, US
Shawn Zinnen - Denver CO, US
Pamela Pavco - Lafayette CO, US
Peter Haeberli - Berthoud CO, US
David Morrissey - Boulder CO, US
Kathy Fosnaugh - Boulder CO, US
Sharon Jamison - Boulder CO, US
Nassim Usman - Lafayette CO, US
James Thompson - Lafayette CO, US
Chandra Vargeese - Broomfield CO, US
Weimin Wang - Superior CO, US
Tongqian Chen - Longmont CO, US
Narendra Vaish - Denver CO, US
Bharat Chowrira - Louisville CO, US
Leonid Beigelman - Brisbane CA, US
Dennis Macejak - Arvada CO, US
Shawn Zinnen - Denver CO, US
Pamela Pavco - Lafayette CO, US
Peter Haeberli - Berthoud CO, US
David Morrissey - Boulder CO, US
Kathy Fosnaugh - Boulder CO, US
Sharon Jamison - Boulder CO, US
Nassim Usman - Lafayette CO, US
James Thompson - Lafayette CO, US
Chandra Vargeese - Broomfield CO, US
Weimin Wang - Superior CO, US
Tongqian Chen - Longmont CO, US
Narendra Vaish - Denver CO, US
Assignee:
Sirna Therapeutics, Inc. - San Francisco CA
International Classification:
A61K 48/00, C07H 21/02, C07F 9/6512
US Classification:
435325000, 514044000, 536023100, 544243000
Abstract:
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
Oligonucleotide Mediated Inhibition Of Hepatitis B Virus And Hepatitis C Virus Replication
US Patent:
2004012, Jul 1, 2004
Filed:
Sep 23, 2003
Appl. No.:
10/669841
Inventors:
Lawrence Blatt - San Francisco CA, US
Dennis Macejak - Arvada CO, US
James McSwiggen - Boulder CO, US
David Morrissey - Boulder CO, US
Pamela Pavco - Lafayette CO, US
Patrice Lee - Erie CO, US
Kenneth Draper - Reno NV, US
Elisabeth Roberts - Federal Heights CO, US
Dennis Macejak - Arvada CO, US
James McSwiggen - Boulder CO, US
David Morrissey - Boulder CO, US
Pamela Pavco - Lafayette CO, US
Patrice Lee - Erie CO, US
Kenneth Draper - Reno NV, US
Elisabeth Roberts - Federal Heights CO, US
International Classification:
A61K048/00, C07H021/02
US Classification:
514/044000, 536/023720
Abstract:
The present invention relates to nucleic acid molecules, including antisense and enzymatic nucleic acid molecules, such as hammerhead ribozymes, DNAzymes, Inozymes, Zinzymes, Amberzymes, and G-cleaver ribozymes, which modulate the synthesis, expression and/or stability of an HCV or HBV RNA and methods for their use alone or in combination with other therapies. In addition, nucleic acid decoy molecules and aptamers that bind to HBV reverse transcriptase and/or HBV reverse transcriptase primer sequences and methods for their use alone or in combination with other therapies, are disclosed. Oligonucleotides that specifically bind the Enhancer I region of HBV DNA are further disclosed. The present invention further relates to the use of nucleic acids, such as decoy and aptamer molecules of the invention, to modulate the expression of Hepatitis B virus (HBV) genes and HBV viral replication. Furthermore, HBV animal models and methods of use are disclosed, including methods of screening for compounds and/or potential therapies directed against HBV. The present invention also relates to compounds, including enzymatic nucleic acid molecules, ribozymes, DNAzymes, nuclease activating compounds and chimeras such as 2′,5′-adenylates, that modulate the expression and/or replication of hepatitis C virus (HCV).
Rna Interference Mediated Inhibition Of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (Sina)
US Patent:
2006021, Sep 28, 2006
Filed:
Feb 21, 2006
Appl. No.:
11/358863
Inventors:
James McSwiggen - Boulder CO, US
Bharat Chowrira - Louisville CO, US
Leonid Beigelman - Longmont CO, US
Dennis Macejak - Arvada CO, US
Shawn Zinnen - Denver CO, US
Pamela Pavco - Lafayette CO, US
Peter Haeberli - Berthoud CO, US
David Morrissey - Boulder CO, US
Kathy Fosnaugh - Boulder CO, US
Sharon Jamison - Boulder CO, US
Nassim Usman - Lafayette CO, US
James Thompson - Lafayette CO, US
Chandra Vargeese - Thorton CO, US
Weimin Wang - Superior CO, US
Tongqian Chen - Longmont CO, US
Narendra Vaish - Boulder CO, US
Bharat Chowrira - Louisville CO, US
Leonid Beigelman - Longmont CO, US
Dennis Macejak - Arvada CO, US
Shawn Zinnen - Denver CO, US
Pamela Pavco - Lafayette CO, US
Peter Haeberli - Berthoud CO, US
David Morrissey - Boulder CO, US
Kathy Fosnaugh - Boulder CO, US
Sharon Jamison - Boulder CO, US
Nassim Usman - Lafayette CO, US
James Thompson - Lafayette CO, US
Chandra Vargeese - Thorton CO, US
Weimin Wang - Superior CO, US
Tongqian Chen - Longmont CO, US
Narendra Vaish - Boulder CO, US
Assignee:
Sirna Therapeutics, Inc. - Boulder CO
International Classification:
A61K 48/00, C07H 21/00, C07F 9/6512
US Classification:
514044000, 536025300, 544243000
Abstract:
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
Rna Interference Mediated Ihibition Of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (Sina)
US Patent:
2006028, Dec 21, 2006
Filed:
Feb 21, 2006
Appl. No.:
11/358862
Inventors:
James McSwiggen - Boulder CO, US
Bharat Chowrira - Louisville CO, US
Leonid Beigelman - Longmont CO, US
Dennis Macejak - Arvada CO, US
Shawn Zinnen - Denver CO, US
Pamela Pavco - Lafayette CO, US
Peter Haeberli - Berthoud CO, US
David Morrissey - Boulder CO, US
Kathy Fosnaugh - Boulder CO, US
Sharon Jamison - Boulder CO, US
Nassim Usman - Lafayette CO, US
James Thompson - Lafayette CO, US
Chandra Vargeese - Thorton CO, US
Weimin Wang - Superior CO, US
Tongqian Chen - Longmont CO, US
Narendra Vaish - Boulder CO, US
Bharat Chowrira - Louisville CO, US
Leonid Beigelman - Longmont CO, US
Dennis Macejak - Arvada CO, US
Shawn Zinnen - Denver CO, US
Pamela Pavco - Lafayette CO, US
Peter Haeberli - Berthoud CO, US
David Morrissey - Boulder CO, US
Kathy Fosnaugh - Boulder CO, US
Sharon Jamison - Boulder CO, US
Nassim Usman - Lafayette CO, US
James Thompson - Lafayette CO, US
Chandra Vargeese - Thorton CO, US
Weimin Wang - Superior CO, US
Tongqian Chen - Longmont CO, US
Narendra Vaish - Boulder CO, US
Assignee:
Sirna Therapeutics, Inc. - Boulder CO
International Classification:
A61K 48/00, C07H 21/02, C07F 9/6512
US Classification:
514044000, 514081000, 536023100, 544243000
Abstract:
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.