Inventors:
Frank J. Rauscher - Wayne PA
David E. Jensen - Philadelphia PA
Assignee:
The Wistar Institute of Anatomy and Biology - Philadelphia PA
International Classification:
C07H 2102, C12N 1500, C12N 120, C12P 2106
Abstract:
Nucleic acid and amino acid sequences of a BRCA1 associated protein, BAP-1, are provided. These sequences, the protein, and anti-BAP-1 antibodies are useful in therapeutics and diagnostics for cancers associated with loss of the 3p21 chromosomal region and/or inappropriate BAP-1 levels.