DAVID C DALE, MD
Osteopathic Medicine at Pacific St, Seattle, WA

2006022, Oct 5, 2006

Jun 2, 2006

11/446390

Gary Bridger - Bellingham WA, US
Michael Abrams - Custer WA, US
Geoffrey Henson - Ferndale WA, US
Ronald MacFarland - Vancouver, CA
Gary Calandra - Cresco PA, US
Hal Broxmeyer - Indianapolis IN, US
David Dale - Seattle WA, US

A61K 31/33, C12N 5/08

435366000, 514183000

Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z′  () or pharmaceutically acceptable salt thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system; or Z is of the formula wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z′ may be embodied in a form as defined by Z above, or alternatively may be of the formula —N(R)—(CR)—X wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; “linker” represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.

2004015, Aug 12, 2004

Jan 26, 2004

10/765306

William Osborne - Seattle WA, US
Randolph Geary - Seattle WA, US
Stella Lau - Seattle WA, US
Alexander Clowes - Seattle WA, US
David Dale - Seattle WA, US

University of Washington

A61K048/00

424/093210

Vascular grafts are used in gene therapy to implant autologous vascular smooth muscle cells that have been transduced with the gene of interest. The smooth muscle cells are immobilized within the pores and upon the interior surface of the wall of the graft, which is then coated with vascular endothelial cells and implanted into a patients's vascular system. The grafting device can be used in methods of treatment, such as supplying erythropoietin to a patient, and can be removed easily and replenished as necessary. The process is readily controlled and significantly reduces the risk of a viral gene vector spreading beyond a target cell population.

8283344, Oct 9, 2012

Sep 5, 2008

12/673588

David C. Dale - Seattle WA, US
Paul E. Finke - Milltown NJ, US
Richard A. Mumford - Red Bank NJ, US
Andranik Andrew Aprikyan - Kenmore WA, US

Merck & Co., Inc. - Rahway NJ
University of Washington - Seattle WA

A01N 43/00, A61K 31/397, A61K 31/407

51421018, 51425501, 51425214, 5142338

The invention is directed to a method of treating severe neutropenia, and in particular, cyclic neutropenia (CN) or severe congenital neutropenia (SCN), in a patient in need of such treatment comprising: administering a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

2011012, Jun 2, 2011

Feb 8, 2011

13/023381

Gary J. BRIDGER - Bellingham WA, US
Michael J. Abrams - Custer WA, US
Geoffrey W. Henson - Ferndale WA, US
Ronald Trevor MacFarland - Vancouver, CA
Gary B. Calandra - Cresco PA, US
Hal E. Broxmeyer - Indianapolis IN, US
David C. Dale - Seattle WA, US

Genzyme Corporation - Cambridge MA

A61K 35/12, A61P 37/00

424 937

Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula

6987102, Jan 17, 2006

Jul 30, 2002

10/209001

Gary J. Bridger - Bellingham WA, US
Michael J. Abrams - Custer WA, US
Geoffrey W. Henson - Ferndale WA, US
Ronald Trevor MacFarland - Vancouver, CA
Gary B. Calandra - Cresco PA, US
Hal E. Broxmeyer - Indianapolis IN, US
David C. Dale - Seattle WA, US

Anormed, Inc. - Langley

A61K 31/33, C07D 245/00, C07D 487/00

514183, 540473, 540474

Certain nitrogen-containing compounds that bind the chemokine receptor CXCR4 are able to mobilize progenitor and/or stem cells into the peripheral blood to permit harvesting them for stem cell transplantation.

7897590, Mar 1, 2011

Aug 20, 2007

11/841837

Gary J. Bridger - Bellingham WA, US
Michael J. Abrams - Custer WA, US
Geoffrey W. Henson - Ferndale WA, US
Ronald Trevor MacFarland - Vancouver, CA
Gary B. Calandra - Cresco PA, US
Hal E. Broxmeyer - Indianapolis IN, US
David C. Dale - Seattle WA, US

Genzyme Corporation - Cambridge MA

A61K 31/33, C07D 245/00, C07D 487/00

514183, 540473, 540474

Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z′  (1).

7935692, May 3, 2011

Nov 8, 2005

11/269773

Gary J. Bridger - Bellingham WA, US
Michael J. Abrams - Custer WA, US
Geoffrey W. Henson - Ferndale WA, US
Ronald Trevor MacFarland - Vancouver, CA
Gary B. Calandra - Cresco PA, US
Hal E. Broxmeyer - Indianapolis IN, US
David C. Dale - Seattle WA, US

Genzyme Corporation - Cambridge MA

A61K 31/33, C07D 245/00, C07D 487/00

514183, 540473, 540474

Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z′  (1).