Inventors:
ZHAOXI WANG - CHELMSFORD MA, US
DOUGLAS BEACH - BROOKLINE MA, US
LI SU - SOMERVILLE MA, US
RIHONG ZHAI - QUINCY MA, US
DAVID C. CHRISTIANI - JAMAICA PLAIN MA, US
Assignee:
HARVARD UNIVERSITY - Cambridge MA
International Classification:
A61K 38/55, C07H 21/00, A61P 11/00, C12Q 1/68, G01N 33/68, C12Q 1/37, C12Q 1/02
US Classification:
514 15, 536 256, 435 6, 436 86, 435 23, 435 29
Abstract:
The subject invention features methods for predicting whether a subject at risk of developing Acute Respiratory Distress Syndrome (ARDS) will develop ARDS by determining the amount of elafin present in a subject sample, or by determining the ration of elafin:neutrophil elastase in a subject sample. The invention also features methods for monitoring the efficacy of a treatment regimen for ARDS as well as methods of treatment for ARDS. The invention also features methods to determine a subject's predisposition for developing ARDS by determining whether certain genomic polymorphisms are present in the subject's DNA.